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Molecules

Title:		Advances in Mid-Infrared Spectroscopy-Based Sensing Techniques for Exhaled Breath Diagnostics
Author(s):		Selvaraj R; Vasa NJ; Nagendra SMS; Mizaikoff B;
Address:		"Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, India. Department of Civil Engineering, Indian Institute of Technology Madras, Chennai 600036, India. Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081 Ulm, Germany"
Journal Title:		Molecules
Year:		2020
Volume:		20200509
Issue:		9
Page Number:		-
DOI:		10.3390/molecules25092227
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Human exhaled breath consists of more than 3000 volatile organic compounds, many of which are relevant biomarkers for various diseases. Although gas chromatography has been the gold standard for volatile organic compound (VOC) detection in exhaled breath, recent developments in mid-infrared (MIR) laser spectroscopy have led to the promise of compact point-of-care (POC) optical instruments enabling even single breath diagnostics. In this review, we discuss the evolution of MIR sensing technologies with a special focus on photoacoustic spectroscopy, and its application in exhaled breath biomarker detection. While mid-infrared point-of-care instrumentation promises high sensitivity and inherent molecular selectivity, the lack of standardization of the various techniques has to be overcome for translating these techniques into more widespread real-time clinical use"
Keywords:		"Biosensing Techniques/*instrumentation Breath Tests Humans Photoacoustic Techniques/instrumentation Point-of-Care Testing Spectrophotometry, Infrared/*instrumentation Volatile Organic Compounds/*analysis Mir Qcl biomarkers exhaled breath analysis infrared;"
Notes:		"MedlineSelvaraj, Ramya Vasa, Nilesh J Nagendra, S M Shiva Mizaikoff, Boris eng GRK2203-PULMOSENS/Deutsche Forschungsgemeinschaft/ Project VOGAS (project number 824986/Horizon 2020 Framework Programme/ IR/S3/EU-01/2009/Joint National Center for Combustion Research and Development (NCCRD)/ Review Switzerland 2020/05/14 Molecules. 2020 May 9; 25(9):2227. doi: 10.3390/molecules25092227"