| Title: | Biological activity of volatiles from marine and terrestrial bacteria |
| Author(s): | Schulz S; Dickschat JS; Kunze B; Wagner-Dobler I; Diestel R; Sasse F; |
| Address: | "Institute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.de" |
| ISSN/ISBN: | 1660-3397 (Electronic) 1660-3397 (Linking) |
| Abstract: | "The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. gamma-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given" |
| Keywords: | Animals Bacteria/*chemistry/*drug effects Cell Proliferation/*drug effects Fibroblasts/*drug effects Lactones/chemistry/pharmacology Mice Oceans and Seas Quorum Sensing/*drug effects Seawater/*microbiology Signal Transduction/drug effects Volatile Organic; |
| Notes: | "MedlineSchulz, Stefan Dickschat, Jeroen S Kunze, Brigitte Wagner-Dobler, Irene Diestel, Randi Sasse, Florenz eng Research Support, Non-U.S. Gov't Switzerland 2011/02/23 Mar Drugs. 2010 Dec 22; 8(12):2976-87. doi: 10.3390/md8122976" |
