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Trends Biotechnol

Title:		Immobilizing proteins on the surface of yeast cells
Author(s):		Schreuder MP; Mooren AT; Toschka HY; Verrips CT; Klis FM;
Address:		"Department of Molecular Cell Biology, University of Amsterdam, Netherlands"
Journal Title:		Trends Biotechnol
Year:		1996
Volume:		14
Issue:		4
Page Number:		115 - 120
DOI:		10.1016/0167-7799(96)10017-2
ISSN/ISBN:		0167-7799 (Print) 0167-7799 (Linking)
Abstract:		"Yeast has a rigid cell wall comprising an outer layer of glycoproteins and an internal skeletal layer of glucan; heterologous proteins can be targeted to the glycoprotein layer and become covalently linked to the glucan skeleton. Yeast is a eukaryote that has 'generally regarded as safe' (GRAS) status, and is easy to cultivate, so it seems ideally suited for applications including the manufacture of recyclable, immobilized, biocatalysts, whole-cell vaccines, the presentation of peptide or antibody libraries, and the presentation of adhesion or metal-binding proteins"
Keywords:		"Administration, Oral Antibodies/genetics/metabolism Biodegradation, Environmental Biotechnology/trends Cell Membrane/*metabolism Enzymes, Immobilized Gene Expression Mannose-Binding Lectins Mating Factor Membrane Proteins/metabolism Peptides/metabolism Re;"
Notes:		"MedlineSchreuder, M P Mooren, A T Toschka, H Y Verrips, C T Klis, F M eng Review England 1996/04/01 Trends Biotechnol. 1996 Apr; 14(4):115-20. doi: 10.1016/0167-7799(96)10017-2"