| Title: | Effect of inhaled acetone concentrations on exhaled breath acetone concentrations at rest and during exercise |
| Author(s): | Ager C; Mochalski P; King J; Mayhew CA; Unterkofler K; |
| Address: | "Institute for Breath Research, Leopold-Franzens-Universitat Innsbruck, Rathausplatz 4, A-6850 Dornbirn, Austria. Univ.-Clinic for Anesthesia and Intensive Care, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated acetone concentration levels, at rest and during exercise, have been conducted using proton transfer reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data of inhaled and exhaled concentrations. The experimental results obtained are compared with those predicted using a simple three compartment model that theoretically describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the predicted and observed concentrations is obtained. Our results highlight that the influence of the upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e. highly water soluble volatiles" |
| Keywords: | Acetone/*analysis Breath Tests/*methods Exercise/*physiology *Exhalation Humans Inhalation Exposure/*analysis Rest/*physiology Time Factors Volatile Organic Compounds/analysis; |
| Notes: | "MedlineAger, Clemens Mochalski, Pawel King, Julian Mayhew, Chris A Unterkofler, Karl eng Clinical Trial Research Support, Non-U.S. Gov't England 2019/12/13 J Breath Res. 2020 Mar 4; 14(2):026010. doi: 10.1088/1752-7163/ab613a" |
