| Title: | Measuring semi-volatile organic compound exposures during pregnancy using silicone wristbands |
| Author(s): | Samon S; Herkert N; Ghassabian A; Liu H; Hammel SC; Trasande L; Stapleton HM; Hoffman K; |
| Address: | "Nicholas School of the Environment, Duke University, Durham, NC, USA. New York University Grossman School of Medicine, New York, NY, USA. Nicholas School of the Environment, Duke University, Durham, NC, USA. Electronic address: kate.hoffman@duke.edu" |
| DOI: | 10.1016/j.chemosphere.2023.139778 |
| ISSN/ISBN: | 1879-1298 (Electronic) 0045-6535 (Linking) |
| Abstract: | "Silicone wristbands were utilized as personal passive samplers in a sub-cohort of 92 women, who participated in New York University Children's Health and Environment Study, to assess exposure to semi-volatile organic compounds (SVOCs). Wristbands were analyzed for 77 SVOCs, including halogenated and non-halogenated organophosphate esters (OPEs), polychlorinated biphenyls (PCBs), pesticides, phthalates, and brominated flame retardants (BFRs) (e.g. polybrominated diphenyl ethers (PBDEs)). This study aimed to look for patterns in chemical exposure utilizing participant demographics gathered from a questionnaire, and chemical exposure data across multiple timepoints during pregnancy. Analysis focused on 27 compounds detected in at least 80% of the wristbands examined. The chemicals detected most frequently included two pesticides, eight phthalates, one phthalate alternative, seven BFRs, and nine OPEs, including isopropylated and tert-butylated triarylphosphate esters (ITPs and TBPPs). Co-exposure to different SVOCs was most prominent in compounds that were within the same chemical class or were used in similar consumer applications such as phthalates and OPEs, which are often used as plasticizers. Pre-pregnancy BMI was positively associated with multiple compounds, and there were both positive and negative associations between women's parity and SVOC exposure. Outdoor temperature was not correlated with the wristband concentrations over a five-day sampling period. Lastly, significant and moderately high Intraclass Correlation Coefficient (ICC) (0.66-0.84) values for phthalate measurementsacross pregnancy indicate chronic exposure and suggest that using wristbands during one sampling period may reliably predict exposure. However, multiple sampling periods may be necessary to accurately determine indoor exposure to other SVOCs including OPEs and BFRs" |
| Keywords: | Child Humans Female Pregnancy Silicones/chemistry Environmental Monitoring *Volatile Organic Compounds/analysis Organophosphates/analysis *Pesticides/analysis *Flame Retardants/analysis Halogenated Diphenyl Ethers/analysis Esters Chemical exposure Semi-vo; |
| Notes: | "MedlineSamon, Samantha Herkert, Nicholas Ghassabian, Akhgar Liu, Hongxiu Hammel, Stephanie C Trasande, Leonardo Stapleton, Heather M Hoffman, Kate eng P42 ES010356/ES/NIEHS NIH HHS/ U2C ES030851/ES/NIEHS NIH HHS/ England 2023/08/12 Chemosphere. 2023 Oct; 339:139778. doi: 10.1016/j.chemosphere.2023.139778. Epub 2023 Aug 9" |
