| Title: | Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes |
| Author(s): | Rubinstein ML; Delucchi K; Benowitz NL; Ramo DE; |
| Address: | "Division of Adolescent Medicine, mark.rubinstein@ucsf.edu. Department of Psychiatry, and. Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California. Division of Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering and Therapeutic Sciences" |
| ISSN/ISBN: | 1098-4275 (Electronic) 0031-4005 (Print) 0031-4005 (Linking) |
| Abstract: | "BACKGROUND: There is an urgent need to understand the safety of e-cigarettes with adolescents. We sought to identify the presence of chemical toxicants associated with e-cigarette use among adolescents. METHODS: Adolescent e-cigarette users (>/=1 use within the past 30 days, >/=10 lifetime e-cigarette use episodes) were divided into e-cigarette-only users (no cigarettes in the past 30 days, urine 4-[methylnitrosamino]-1-[3-pyridyl]-1-butanol [NNAL] level <1 pg/mL of creatinine; n = 67), dual users (use of cigarettes in the past 30 days in addition to e-cigarettes, NNAL level >30 pg/mL; n = 16), and never-using controls (N = 20). Saliva was collected within 24 hours of the last e-cigarette use for analysis of cotinine and urine for analysis of NNAL and levels of 8 volatile organic chemical compounds. Bivariate analyses compared e-cigarette-only users with dual users, and regression analyses compared e-cigarette-only users with dual users and controls on levels of toxicants. RESULTS: The participants were 16.4 years old on average. Urine excretion of metabolites of benzene, ethylene oxide, acrylonitrile, acrolein, and acrylamide was significantly higher in dual users versus e-cigarette-only users (all P < .05). Excretion of metabolites of acrylonitrile, acrolein, propylene oxide, acrylamide, and crotonaldehyde were significantly higher in e-cigarette-only users compared with controls (all P < .05). CONCLUSIONS: Although e-cigarette vapor may be less hazardous than tobacco smoke, our findings can be used to challenge the idea that e-cigarette vapor is safe, because many of the volatile organic compounds we identified are carcinogenic. Messaging to teenagers should include warnings about the potential risk from toxic exposure to carcinogenic compounds generated by these products" |
| Keywords: | Adolescent Adolescent Behavior/*drug effects/physiology Biomarkers/urine Electronic Nicotine Delivery Systems/methods Female Humans Longitudinal Studies Male Saliva/drug effects/metabolism Tobacco Products/adverse effects/toxicity Vaping/*adverse effects/; |
| Notes: | "MedlineRubinstein, Mark L Delucchi, Kevin Benowitz, Neal L Ramo, Danielle E eng P30 DA012393/DA/NIDA NIH HHS/ R21 DA040718/DA/NIDA NIH HHS/ P50 CA180890/CA/NCI NIH HHS/ S10 RR026437/RR/NCRR NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2018/03/07 Pediatrics. 2018 Apr; 141(4):e20173557. doi: 10.1542/peds.2017-3557. Epub 2018 Mar 5" |
