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Int J Mol Sci


Title:New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity towards Colon Cancer
Author(s):Ruberte AC; Gonzalez-Gaitano G; Sharma AK; Aydillo C; Encio I; Sanmartin C; Plano D;
Address:"Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Irunlarrea 3, E-31008 Pamplona, Spain. Department of Chemistry, University of Navarra, 31080 Pamplona, Spain. Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, Hershey, PA 17036, USA. Department of Health Sciences, Public University of Navarra, Avda. Baranain s/n, E-31008 Pamplona, Spain"
Journal Title:Int J Mol Sci
Year:2020
Volume:20201127
Issue:23
Page Number: -
DOI: 10.3390/ijms21239017
ISSN/ISBN:1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:"Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA has greatly increased their anti-tumoral efficacy in CRC compared with the organic counterparts without the Se functionality, such as the promising antitumoral methylseleno-ASA analog (1a). Nevertheless, the efficacy of compound 1a in cancer cells is compromised due to its poor solubility and volatile nature. Thus, 1a has been formulated with native alpha-, beta- and gamma-cyclodextrin (CD), a modified beta-CD (hydroxypropyl beta-CD, HP-beta-CD) and Pluronic F127, all of them non-toxic, biodegradable and FDA approved. Water solubility of 1a is enhanced with beta- and HP- beta-CDs and Pluronic F127. Compound 1a forms inclusion complexes with the CDs and was incorporated in the hydrophobic core of the F127 micelles. Herein, we evaluated the cytotoxic potential of 1a, alone or formulated with beta- and HP- beta-CDs or Pluronic F127, against CRC cells. Remarkably, 1a formulations demonstrated more sustained antitumoral activity toward CRC cells. Hence, beta-CD, HP-beta-CD and Pluronic F127 might be excellent vehicles to improve pharmacological properties of organoselenium compounds with solubility issues and volatile nature"
Keywords:Antineoplastic Agents/chemistry/pharmacology/*therapeutic use Aspirin/chemistry/pharmacology/*therapeutic use Cell Proliferation/drug effects Colonic Neoplasms/*drug therapy Drug Liberation HT29 Cells Humans Micelles Poloxamer/chemistry Proton Magnetic Re;
Notes:"MedlineRuberte, Ana Carolina Gonzalez-Gaitano, Gustavo Sharma, Arun K Aydillo, Carlos Encio, Ignacio Sanmartin, Carmen Plano, Daniel eng 2018-21/Universidad de Navarra (PIUNA)/ P/12/19/Universidad Nacional de Educacion a Distancia (UNED)/ Switzerland 2020/12/03 Int J Mol Sci. 2020 Nov 27; 21(23):9017. doi: 10.3390/ijms21239017"

 
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