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Molecules

Title:		Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto
Author(s):		Rodriguez-Cisneros M; Morales-Ruiz LM; Salazar-Gomez A; Rojas-Rojas FU; Estrada-de Los Santos P;
Address:		"Departamento de Microbiologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomas Alc. Miguel Hidalgo, Ciudad de Mexico 11340, Mexico. Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico (ENES-Leon UNAM), Blvd. UNAM 2011, Leon, Guanajuato 37684, Mexico. Laboratorio de Ciencias AgroGenomicas, Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico (ENES-Leon UNAM), Blvd. UNAM 2011, Leon, Guanajuato 37684, Mexico. Laboratorio Nacional PlanTECC, Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico (ENES-Leon UNAM), Blvd. UNAM 2011, Leon, Guanajuato 37684, Mexico"
Journal Title:		Molecules
Year:		2023
Volume:		20230208
Issue:		4
Page Number:		-
DOI:		10.3390/molecules28041646
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae are in the 'critical' (most urgent) category. As a result, major investigations are ongoing worldwide to discover new antimicrobial compounds. Burkholderia, specifically Burkholderia sensu stricto, is recognized as an antimicrobial-producing group of species. Highly dissimilar compounds are among the molecules produced by this genus, such as those that are unique to a particular strain (like compound CF66I produced by Burkholderia cepacia CF-66) or antimicrobials found in a number of species, e.g., phenazines or ornibactins. The compounds produced by Burkholderia include N-containing heterocycles, volatile organic compounds, polyenes, polyynes, siderophores, macrolides, bacteriocins, quinolones, and other not classified antimicrobials. Some of them might be candidates not only for antimicrobials for both bacteria and fungi, but also as anticancer or antitumor agents. Therefore, in this review, the wide range of antimicrobial compounds produced by Burkholderia is explored, focusing especially on those compounds that were tested in vitro for antimicrobial activity. In addition, information was gathered regarding novel compounds discovered by genome-guided approaches"
Keywords:		*Burkholderia *Anti-Infective Agents Anti-Bacterial Agents *Burkholderia cepacia *Bacteriocins Burkholderia sensu stricto antimicrobials non-ribosomal peptides;
Notes:		"MedlineRodriguez-Cisneros, Mariana Morales-Ruiz, Leslie Mariana Salazar-Gomez, Anuar Rojas-Rojas, Fernando Uriel Estrada-de Los Santos, Paulina eng 2021-0392, 2022-0660/Instituto Politecnico Nacional/ Review Switzerland 2023/02/26 Molecules. 2023 Feb 8; 28(4):1646. doi: 10.3390/molecules28041646"