| Title: | Characterization and coding of behaviorally significant odor mixtures |
| Author(s): | Riffell JA; Lei H; Christensen TA; Hildebrand JG; |
| Address: | "University of Arizona, Tucson, 85721, USA. jeffr@neurobio.arizona.edu" |
| DOI: | 10.1016/j.cub.2009.01.041 |
| ISSN/ISBN: | 1879-0445 (Electronic) 0960-9822 (Print) 0960-9822 (Linking) |
| Abstract: | "For animals to execute odor-driven behaviors, the olfactory system must process complex odor signals and maintain stimulus identity in the face of constantly changing odor intensities [1-5]. Surprisingly, how the olfactory system maintains identity of complex odors is unclear [6-10]. We took advantage of the plant-pollinator relationship between the Sacred Datura (Datura wrightii) and the moth Manduca sexta[11, 12] to determine how olfactory networks in this insect's brain represent odor mixtures. We combined gas chromatography and neural-ensemble recording in the moth's antennal lobe to examine population codes for the floral mixture and its fractionated components. Although the floral scent of D. wrightii comprises at least 60 compounds, only nine of those elicited robust neural responses. Behavioral experiments confirmed that these nine odorants mediate flower-foraging behaviors, but only as a mixture. Moreover, the mixture evoked equivalent foraging behaviors over a 1000-fold range in dilution, suggesting a singular percept across this concentration range. Furthermore, neural-ensemble recordings in the moth's antennal lobe revealed that reliable encoding of the floral mixture is organized through synchronized activity distributed across a population of glomerular coding units, and this timing mechanism may bind the features of a complex stimulus into a coherent odor percept" |
| Keywords: | "Action Potentials/physiology Animals Behavior, Animal/*physiology Datura/chemistry Electrophysiology Flight, Animal Male Manduca/physiology Odorants Olfactory Pathways/*physiology Olfactory Receptor Neurons/physiology Receptors, Odorant/metabolism Smell/*;" |
| Notes: | "MedlineRiffell, Jeffrey A Lei, Hong Christensen, Thomas A Hildebrand, John G eng DC-02751/DC/NIDCD NIH HHS/ R01 DC002751/DC/NIDCD NIH HHS/ R01 DC002751-14A1/DC/NIDCD NIH HHS/ K12 GM000708/GM/NIGMS NIH HHS/ 2 K12 GM000708-06/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2009/02/24 Curr Biol. 2009 Feb 24; 19(4):335-40. doi: 10.1016/j.cub.2009.01.041" |
