« Previous AbstractCharacterization of Antimicrobial-Producing Beneficial Bacteria Isolated from Huanglongbing Escape Citrus Trees    Next Abstract"Experimental setup and analytical methods for the non-invasive determination of volatile organic compounds, formaldehyde and NOx in exhaled human breath" »

Vet Parasitol

Title:		Bovine IgG subclasses and fertility of Echinococcus granulosus hydatid cysts
Author(s):		Riesle S; Garcia MP; Hidalgo C; Galanti N; Saenz L; Paredes R;
Address:		"Escuela de Medicina Veterinaria, Facultad de Ecologia y Recursos Naturales, Universidad Andres Bello, Santiago, Chile; Cambridge Infectious Diseases, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK. Escuela de Medicina Veterinaria, Facultad de Ecologia y Recursos Naturales, Universidad Andres Bello, Santiago, Chile. Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Laboratorio de Vacunas Veterinarias, Departamento Ciencias Biologicas Animales, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile. Escuela de Medicina Veterinaria, Facultad de Ecologia y Recursos Naturales, Universidad Andres Bello, Santiago, Chile. Electronic address: rparedes@unab.cl"
Journal Title:		Vet Parasitol
Year:		2014
Volume:		20140610
Issue:		1-Feb
Page Number:		125 - 133
DOI:		10.1016/j.vetpar.2014.06.003
ISSN/ISBN:		1873-2550 (Electronic) 0304-4017 (Linking)
Abstract:		"Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts. In the germinal layer of infertile cysts IgGs are found in an order of magnitude greater than in the germinal layer of fertile cysts; a fraction of those IgGs are associated with high affinity to germinal layer proteins, suggesting their binding to specific parasite antigens. We have previously shown that those immunoglobulins, bound with high affinity to the germinal layer of hydatid cysts, induce apoptosis leading to cyst infertility. In the present work the presence of IgG1 and IgG2 subclasses in the germinal layer of both fertile and infertile hydatid cysts is reported. IgG1 is the most relevant immunoglobulin subclass present in the germinal layer of infertile cysts and bound with high affinity to that parasite structure. Contrarily, though the IgG2 subclass was also found in the germinal and adventitial layers, those immunoglobulins show low affinity to parasite antigens. We propose that the binding of an IgG1 subclass to parasite antigens present in the germinal layer is involved in the mechanism of cyst infertility"
Keywords:		"Animals Antibodies, Helminth/*classification Cattle Cattle Diseases/*parasitology Echinococcosis/parasitology/*veterinary Echinococcus granulosus/*immunology Immunoglobulin G/*blood/classification Cyst fertility Echinococcus granulosus IgG subclass;"
Notes:		"MedlineRiesle, Silke Garcia, Maria Pia Hidalgo, Christian Galanti, Norbel Saenz, Leonardo Paredes, Rodolfo eng Research Support, Non-U.S. Gov't Netherlands 2014/06/26 Vet Parasitol. 2014 Sep 15; 205(1-2):125-33. doi: 10.1016/j.vetpar.2014.06.003. Epub 2014 Jun 10"