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Atmos Environ (1994)

Title:		Mutagenic atmospheres resulting from the photooxidation of aromatic hydrocarbon and NO(x) mixtures
Author(s):		Riedel TP; DeMarini DM; Zavala J; Warren SH; Corse EW; Offenberg JH; Kleindienst TE; Lewandowski M;
Address:		"National Exposure Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States. National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States. Oak Ridge Institute for Science and Education, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States. Jacobs Technology, Cary, North Carolina, United States"
Journal Title:		Atmos Environ (1994)
Year:		2018
Volume:		178
Issue:
Page Number:		164 - 172
DOI:		10.1016/j.atmosenv.2018.01.052
ISSN/ISBN:		1352-2310 (Print) 1352-2310 (Linking)
Abstract:		"Although many volatile organic compounds (VOCs) are regulated to limit air pollution and the consequent health effects, the photooxidation products generally are not. Thus, we examined the mutagenicity in Salmonella TA100 of photochemical atmospheres generated in a steady-state atmospheric simulation chamber by irradiating mixtures of single aromatic VOCs, NO(x), and ammonium sulfate seed aerosol in air. The 10 VOCs examined were benzene; toluene; ethylbenzene; o-, m-, and p-xylene; 1,2,4- and 1,3,5-trimethylbenzene; m-cresol; and naphthalene. Salmonella were exposed at the air-agar interface to the generated atmospheres for 1, 2, 4, 8, or 16 h. Dark-control exposures produced non-mutagenic atmospheres, illustrating that the gas-phase precursor VOCs were not mutagenic at the concentrations tested. Under irradiation, all but m-cresol and naphthalene produced mutagenic atmospheres, with potencies ranging from 2.0 (p-xylene) to 10.4 (ethylbenzene) revertants m(3) mgC(-1) h(-1). The mutagenicity was due exclusively to direct-acting late-generation products of the photooxidation reactions. Gas-phase chemical analysis showed that a number of oxidized organic chemical species enhanced during the irradiated exposure experiments correlated (r >/= 0.81) with the mutagenic potencies of the atmospheres. Molecular formulas assigned to these species indicated that they likely contained peroxy acid, aldehyde, alcohol, and other functionalities"
Keywords:		Air quality Aromatic hydrocarbons Mutagenicity Photooxidation products Salmonella TA100;
Notes:		"PubMed-not-MEDLINERiedel, Theran P DeMarini, David M Zavala, Jose Warren, Sarah H Corse, Eric W Offenberg, John H Kleindienst, Tadeusz E Lewandowski, Michael eng EP-C-15-008/EPA/EPA/ EPA999999/ImEPA/Intramural EPA/ England 2018/05/05 Atmos Environ (1994). 2018 Apr; 178:164-172. doi: 10.1016/j.atmosenv.2018.01.052"