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Conf Proc IEEE Eng Med Biol Soc

Title:		Ant colony optimization for biomarker identification from MALDI-TOF mass spectra
Author(s):		Ressom HW; Varghese RS; Orvisky E; Drake SK; Hortin GL; Abdel-Hamid M; Loffredo CA; Goldman R;
Address:		"Lombardi Comprehensive Cancer Center, Georgetown Univ., Washington, DC, USA. hwr@georgetown.edu"
Journal Title:		Conf Proc IEEE Eng Med Biol Soc
Year:		2006
Volume:		2006
Issue:
Page Number:		4560 - 4563
DOI:		10.1109/IEMBS.2006.260707
ISSN/ISBN:		1557-170X (Print) 1557-170X (Linking)
Abstract:		We present a novel method that combines ant colony optimization with support vector machines (ACO-SVM) to select candidate biomarkers from MALDI-TOF serum profiles of hepatocellular carcinoma (HCC) patients and matched controls. The method identified relevant mass points that achieve high sensitivity and specificity in distinguishing HCC patients from healthy individuals. The results indicate that the MALDI-TOF technology could provide the means to discover novel biomarkers for HCC
Keywords:		"Animals Ants Biomarkers/*chemistry Biomarkers, Tumor/*chemistry Carcinoma, Hepatocellular/diagnosis/*metabolism Humans Mass Spectrometry Peptides/chemistry Pheromones ROC Curve Reproducibility of Results Sensitivity and Specificity Signal Processing, Comp;"
Notes:		"MedlineRessom, Habtom W Varghese, Rency S Orvisky, Eduard Drake, Steven K Hortin, Glen L Abdel-Hamid, Mohamed Loffredo, Christopher A Goldman, Radoslav eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2007/10/20 Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:4560-3. doi: 10.1109/IEMBS.2006.260707"