| Title: | Olfactory circuits and behaviors of nematodes |
| Address: | "Department of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, Los Angeles, CA 90095, United States. Department of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: ehallem@ucla.edu" |
| DOI: | 10.1016/j.conb.2016.09.002 |
| ISSN/ISBN: | 1873-6882 (Electronic) 0959-4388 (Print) 0959-4388 (Linking) |
| Abstract: | "Over one billion people worldwide are infected with parasitic nematodes. Many parasitic nematodes actively search for hosts to infect using volatile chemical cues, so understanding the olfactory signals that drive host seeking may elucidate new pathways for preventing infections. The free-living nematode Caenorhabditis elegans is a powerful model for parasitic nematodes: because sensory neuroanatomy is conserved across nematode species, an understanding of the microcircuits that mediate olfaction in C. elegans may inform studies of olfaction in parasitic nematodes. Here we review circuit mechanisms that allow C. elegans to respond to odorants, gases, and pheromones. We also highlight work on the olfactory behaviors of parasitic nematodes that lays the groundwork for future studies of their olfactory microcircuits" |
| Keywords: | "Animals Behavior, Animal/*physiology Caenorhabditis elegans/physiology Chemotaxis Nematoda/anatomy & histology/*physiology Olfactory Nerve/physiology Smell/*physiology;" |
| Notes: | "MedlineRengarajan, Sophie Hallem, Elissa A eng DP2 DC014596/DC/NIDCD NIH HHS/ F30 GM116810/GM/NIGMS NIH HHS/ T32 GM008042/GM/NIGMS NIH HHS/ T32 NS058280/NS/NINDS NIH HHS/ Review England 2016/09/27 Curr Opin Neurobiol. 2016 Dec; 41:136-148. doi: 10.1016/j.conb.2016.09.002. Epub 2016 Sep 23" |
