| Title: | Mnemons and the memorization of past signaling events |
| Address: | "School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. Electronic address: f.caudron@qmul.ac.uk" |
| DOI: | 10.1016/j.ceb.2021.01.005 |
| ISSN/ISBN: | 1879-0410 (Electronic) 0955-0674 (Linking) |
| Abstract: | "Current advances are raising our awareness of the diverse roles that protein condensation plays in the biology of cells. Particularly, findings in organisms as diverse as yeast and Drosophila suggest that cells may utilize protein condensation to establish long-lasting changes in cellular activities and thereby encode a memory of past signaling events. Proteins that oligomerize to confer such cellular memory have been termed 'mnemons'. In the forming of super-assemblies, mnemons change their function and modulate the influence that the affected protein originally had on cellular processes. Because mnemon assemblies are self-templating, they allow cells to retain the memory of past decisions over larger timescales. Here, we review the mechanisms behind the formation of cellular memory with an emphasis on mnemon-mediated memorization of past signaling events" |
| Keywords: | Proteins Saccharomyces cerevisiae *Signal Transduction Cellular memory Pheromone signalling Protein condensation mRNA binding proteins mnemon; |
| Notes: | "MedlineReichert, Polina Caudron, Fabrice eng BB/S001204/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't Review England 2021/02/23 Curr Opin Cell Biol. 2021 Apr; 69:127-135. doi: 10.1016/j.ceb.2021.01.005. Epub 2021 Feb 20" |
