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Chem Senses

Title:		"Guanosine 3',5'-cyclic monophosphate reduces the response of the Moth's olfactory receptor neuron to pheromone"
Author(s):		Redkozubov A;
Address:		"Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow district, Russia. redkozub@ipac.ac.ru"
Journal Title:		Chem Senses
Year:		2000
Volume:		25
Issue:		4
Page Number:		381 - 385
DOI:		10.1093/chemse/25.4.381
ISSN/ISBN:		0379-864X (Print) 0379-864X (Linking)
Abstract:		"The effects of the membrane-permeable dibutyryl guanosine 3', 5'-cyclic monophosphate (db-cGMP) on the bombykol-elicited receptor current and nerve impulse activity were studied using the open sensillum recording technique. db-cGMP was applied to the outer dendritic membrane of the olfactory receptor neuron of the moth Bombyx mori. db-cGMP reduced the amplitude of the overall receptor current activated by a pulse of strong pheromone stimuli as well as diminished the nerve impulse frequency elicited by continuously applied weak pheromone stimuli. The observed inhibition of the response to pheromone was due to size reduction of an elementary receptor current that elicits the nerve impulses and underlies the overall receptor current. It is suggested that cGMP is a factor which may adjust cell sensitivity to odour and play a role in olfactory adaptation"
Keywords:		Action Potentials/drug effects Animals Bombyx Cyclic GMP/*pharmacology Dibutyryl Cyclic GMP/pharmacology Olfactory Receptor Neurons/*drug effects/physiology Pheromones/*pharmacology Sensory Thresholds/drug effects;
Notes:		"MedlineRedkozubov, A eng Research Support, Non-U.S. Gov't England 2000/08/17 Chem Senses. 2000 Aug; 25(4):381-5. doi: 10.1093/chemse/25.4.381"