| Title: | "Isoarnottinin 4'-glucoside, a glycosylated coumarin from Prangos uloptera, with biological activity" |
| Author(s): | Razavi SM; Zarrini G; Rad FG; |
| Address: | "Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. razavi694@gmail.com" |
| DOI: | 10.1134/s1068162011020130 |
| ISSN/ISBN: | 0132-3423 (Print) 0132-3423 (Linking) |
| Abstract: | "Coumarins are a well-known group of natural products distributed in the plant kingdom especially in the family Apiaceae with various biological activities. Isoarnottinin 4'-glucoside is a simple glycosylated coumarin found previously in a few genera of Apiaceae, and its biological activities have not been previously described in details. In the present paper, the compound was isolated from Prangos uloptera (Apiaceae) leaves using HPLC techniques. Antimicrobial, phytotoxic and cytotoxic activities of the compound were evaluated by disk diffusion, lettuce assay and MTT method. Our results indicated that the compound has high antibacterial effect against Erwinia carotovora, a common plant pathogen with MIC value of 100 microg/mL. The compound also exhibited significant phytotoxic activity against lettuce and modest cytotoxic activity against HeLa cell line with IC50 of 0 .84 mg/mL. It could be concluded that isoamottinin 4'-glucoside may play phytoalexin or allelopathic role for plant and may be a candidate for an antibacterial agent or a bioherbicide" |
| Keywords: | "Anti-Bacterial Agents/chemistry/*metabolism/therapeutic use Apiaceae/*physiology Apoptosis/drug effects Cell Growth Processes/drug effects Chromatography, High Pressure Liquid Coumarins/chemistry/*metabolism/therapeutic use Enterobacteriaceae Infections/*;" |
| Notes: | "MedlineRazavi, Seyed Mehdi Zarrini, Gholamreza Rad, Farah Gholami eng Russia (Federation) 2011/07/02 Bioorg Khim. 2011 Mar-Apr; 37(2):269-72. doi: 10.1134/s1068162011020130" |
