| Title: | Chemical characterisation of aerosols emitted by electronic cigarettes using thermal desorption-gas chromatography-time of flight mass spectrometry |
| Author(s): | Rawlinson C; Martin S; Frosina J; Wright C; |
| Address: | "British American Tobacco, Research & Development, Southampton, UK. British American Tobacco, Research & Development, Southampton, UK. Electronic address: Justin_Frosina@bat.com" |
| DOI: | 10.1016/j.chroma.2017.02.050 |
| ISSN/ISBN: | 1873-3778 (Electronic) 0021-9673 (Linking) |
| Abstract: | "A non-targeted analytical method, using thermal desorption-gas chromatography-time of flight mass spectrometry, to detect, identify and semi-quantify volatile and semi-volatile organic constituents of e-cigarette aerosols is presented. A heart-cutting process with a Deans Switch has been applied to avoid saturation of the mass analyser by high-abundance bulk components. Between 30 and 90 compounds were detected in four aerosol samples generated by e-cigarettes, depending on the added flavourings. The method analyses in a single 80mL, 3-second puff, GC-amenable compounds with volatilities ranging between those of propane (C3) and octacosane (C28) and abundance greater than approximately 5ng. Method sensitivity is suitable for the application of thresholds of toxicological concern for product assessment at an exposure threshold of 1.5mug per day. The method is compatible with the high-throughput screening of GC-amenable compounds in e-cigarette aerosols" |
| Keywords: | Aerosols/*chemistry *Electronic Nicotine Delivery Systems Flavoring Agents/*analysis/chemistry Gas Chromatography-Mass Spectrometry/*methods Herbicides/analysis/chemistry Phthalazines/analysis/chemistry Polycyclic Aromatic Hydrocarbons/analysis/chemistry; |
| Notes: | "MedlineRawlinson, Christopher Martin, Stuart Frosina, Justin Wright, Chris eng Netherlands 2017/04/07 J Chromatogr A. 2017 May 12; 1497:144-154. doi: 10.1016/j.chroma.2017.02.050. Epub 2017 Apr 3" |
