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Sci Rep

Title:		Micro-Chamber/Thermal Extractor (micro-CTE) as a new sampling system for VOCs emitted by feces
Author(s):		Ratiu IA; Mametov R; Ligor T; Buszewski B;
Address:		"Interdisciplinary Centre of Modern Technologies - BioSep, Nicolaus Copernicus University, Wilenska 4, 87-100, Torun, Poland. andreea_ratiu84@yahoo.com. Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100, Torun, Poland. andreea_ratiu84@yahoo.com. 'Raluca Ripan' Institute for Research in Chemistry, Babes-Bolyai University, 30 Fantanele, 400239, Cluj Napoca, Romania. andreea_ratiu84@yahoo.com. Interdisciplinary Centre of Modern Technologies - BioSep, Nicolaus Copernicus University, Wilenska 4, 87-100, Torun, Poland. Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100, Torun, Poland. Interdisciplinary Centre of Modern Technologies - BioSep, Nicolaus Copernicus University, Wilenska 4, 87-100, Torun, Poland. bbusz@chem.umk.pl. Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100, Torun, Poland. bbusz@chem.umk.pl"
Journal Title:		Sci Rep
Year:		2021
Volume:		20210921
Issue:		1
Page Number:		18780 -
DOI:		10.1038/s41598-021-98279-z
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"VOCs (volatile organic compounds) are increasingly wished to be used in diagnosis of diseases. They present strategic advantages, when compared to classical methods used, such as simplicity and current availability of performant non-invasive sample collection methods/systems. However, standardized sampling methods are required in order to achieve reproducible results. In the current study we developed a method to be used for feces sampling using a Micro-Chamber/Thermal Extractor (micro-CTE). Design Expert software (with Box-Behnken design) was used to predict the solutions. Therefore, by using the simulation experimental plan that was further experimentally verified, extraction time of 19.6 min, at extraction temperature of 30.6 degrees C by using a flow rate of 48.7 mL/min provided the higher response. The developed method was validated by using correlation tests and Network analysis, which both proved the validity of the developed model"
Keywords:		Biomarkers/metabolism Feces/*chemistry Gas Chromatography-Mass Spectrometry/methods Humans Volatile Organic Compounds/*analysis;
Notes:		"MedlineRatiu, Ileana Andreea Mametov, Radik Ligor, Tomasz Buszewski, Boguslaw eng Research Support, Non-U.S. Gov't England 2021/09/23 Sci Rep. 2021 Sep 21; 11(1):18780. doi: 10.1038/s41598-021-98279-z"