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Paediatr Respir Rev

Title:		Biomarkers in Paediatric Cystic Fibrosis Lung Disease
Author(s):		Ramsey KA; Schultz A; Stick SM;
Address:		"Telethon Kids Institute, University of Western Australia, Australia; Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, North Carolina, USA. Telethon Kids Institute, University of Western Australia, Australia; Princess Margaret Hospital for Children, Western Australia, Australia; School of Paediatric and Child Health, University of Western Australia, Australia. Telethon Kids Institute, University of Western Australia, Australia; Princess Margaret Hospital for Children, Western Australia, Australia; School of Paediatric and Child Health, University of Western Australia, Australia. Electronic address: Stephen.Stick@health.wa.gov.au"
Journal Title:		Paediatr Respir Rev
Year:		2015
Volume:		20150512
Issue:		4
Page Number:		213 - 218
DOI:		10.1016/j.prrv.2015.05.004
ISSN/ISBN:		1526-0550 (Electronic) 1526-0542 (Linking)
Abstract:		"Biomarkers in cystic fibrosis are used i. for the measurement of cystic fibrosis transmembrane regulator function in order to diagnose cystic fibrosis, and ii. to assess aspects of lung disease severity (e.g. inflammation, infection). Effective biomarkers can aid disease monitoring and contribute to the development of new therapies. The tests of cystic fibrosis transmembrane regulator function each have unique strengths and weaknesses, and biomarkers of inflammation, infection and tissue destruction have the potential to enhance the management of cystic fibrosis through the early detection of disease processes. The development of biomarkers of cystic fibrosis lung disease, in particular airway inflammation and infection, is influenced by the challenges of obtaining relevant samples from infants and children for whom early detection and treatment of disease might have the greatest long term benefits"
Keywords:		"Antibodies, Bacterial/metabolism Biomarkers/*metabolism Breath Tests Bronchoalveolar Lavage Fluid/chemistry Child Cystic Fibrosis/*metabolism Humans Inflammation/metabolism Lung/microbiology Metabolomics Microbiota Pseudomonas/immunology RNA, Ribosomal, 1;"
Notes:		"MedlineRamsey, Kathryn A Schultz, Andre Stick, Stephen M eng Review England 2015/06/09 Paediatr Respir Rev. 2015 Sep; 16(4):213-8. doi: 10.1016/j.prrv.2015.05.004. Epub 2015 May 12"