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Microb Pathog

Title:		Antimicrobial profiling of coral reef and sponge associated bacteria from southeast coast of India
Author(s):		Rajasabapathy R; Ghadi SC; Manikandan B; Mohandass C; Surendran A; Dastager SG; Meena RM; James RA;
Address:		"Department of Marine Science, Bharathidasan University, Tiruchirappalli, 620024, Tamilnadu, India; Department of Biotechnology, Goa University, Taleigao Plateau, 403 206, Goa, India. Electronic address: sabajuly06@gmail.com. Department of Biotechnology, Goa University, Taleigao Plateau, 403 206, Goa, India. Biological Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, 403004, Goa, India. Biological Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, 403004, Goa, India; CSIR-National Institute of Oceanography, Regional Centre, Lokhandwala Road, Four Bungalows, Andheri (West), Mumbai, 400 053, India. Biological Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, 403004, Goa, India; Department of Marine Microbiology, Kerala University of Fisheries and Ocean Studies, Kerala, 682506, India. NCIM Resource Center, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India. Department of Marine Science, Bharathidasan University, Tiruchirappalli, 620024, Tamilnadu, India. Electronic address: james.msbdu@gmail.com"
Journal Title:		Microb Pathog
Year:		2020
Volume:		20200108
Issue:
Page Number:		103972 -
DOI:		10.1016/j.micpath.2020.103972
ISSN/ISBN:		1096-1208 (Electronic) 0882-4010 (Linking)
Abstract:		"Culturable bacteria associated with marine sponges and coral mucus (collected from Gulf of Mannar and Palk Bay) were screened for their prospective antimicrobial compounds against 9 bacterial pathogens (Bacillus megaterium, B. cereus, Salmonella typhimurium, Staphylococcus aureus, Proteus vulgaris, Klebsillla pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii) and a fungal pathogen (Candida albicans). Of the 263 bacterial isolates obtained during this study, 52 isolates displayed antimicrobial activity against one or more pathogens. 16S rRNA gene sequencing revealed that these 52 strains affiliated to 14 genera from three phyla Proteobacteria, Firmicutes and Actinobacteria. Sponge associated bacterial strains F-04, I-23, I-33 and G-03 inhibited the growth of all the bacterial pathogens tested in this study and significantly the former 2 strains inhibited the growth of fungal pathogen also. Majority of the potential strains (88.4% out of 52 strains) inhibited the growth of Bacillus cereus. Interestingly, an actinomycete strain F-04 (isolated from sponge Orina sagittaria) inhibited the growth of methicillin resistant Staphylococcus aureus. In total, 10 volatile organic compounds were determined from the ethyl acetate and hexane extract of the strain F-04 using GC-MS. Overall, marine bacteria isolated during this study demonstrate the potential for the development of broad spectrum antibiotics"
Keywords:		Animals Anti-Infective Agents/isolation & purification/*pharmacology Bacteria/*drug effects/isolation & purification Biodiversity Biological Products/isolation & purification/*pharmacology Chemical Fractionation *Coral Reefs Gas Chromatography-Mass Spectr;
Notes:		"MedlineRajasabapathy, Raju Ghadi, Sanjeev C Manikandan, Balakrishnan Mohandass, Chellandi Surendran, Akhila Dastager, Syed G Meena, Ram M James, Rathinam Arthur eng England 2020/01/11 Microb Pathog. 2020 Apr; 141:103972. doi: 10.1016/j.micpath.2020.103972. Epub 2020 Jan 8"