| Title: | "A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis" |
| Author(s): | Qiu XQ; Zhang J; Wang H; Wu GY; |
| Address: | "Laboratory of Biomembrane and Membrane Protein, West China Hospital, Chengdu, People's Republic of China" |
| Journal Title: | Antimicrob Agents Chemother |
| DOI: | 10.1128/AAC.49.3.1184-1189.2005 |
| ISSN/ISBN: | 0066-4804 (Print) 1098-6596 (Electronic) 0066-4804 (Linking) |
| Abstract: | "A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died" |
| Keywords: | Anti-Bacterial Agents/*pharmacology Base Sequence Colicins/pharmacology Enterococcus faecalis/*drug effects Microbial Sensitivity Tests Molecular Sequence Data *Peptides Protein Engineering *Vancomycin Resistance; |
| Notes: | "MedlineQiu, Xiao-Qing Zhang, Jie Wang, He Wu, George Y eng R01 DK042182/DK/NIDDK NIH HHS/ Research Support, Non-U.S. Gov't 2005/02/25 Antimicrob Agents Chemother. 2005 Mar; 49(3):1184-9. doi: 10.1128/AAC.49.3.1184-1189.2005" |
