| Title: | Artificial Olfactory Biohybrid System: An Evolving Sense of Smell |
| Author(s): | Qin C; Wang Y; Hu J; Wang T; Liu D; Dong J; Lu Y; |
| Address: | "Key Laboratory of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China. Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China" |
| ISSN/ISBN: | 2198-3844 (Electronic) 2198-3844 (Linking) |
| Abstract: | "The olfactory system can detect and recognize tens of thousands of volatile organic compounds (VOCs) at low concentrations in complex environments. Bioelectronic nose (B-EN), which mimics olfactory systems, is becoming an emerging sensing technology for identifying VOCs with sensitivity and specificity. B-ENs integrate electronic sensors with bioreceptors and pattern recognition technologies to enable medical diagnosis, public security, environmental monitoring, and food safety. However, there is currently no commercially available B-EN on the market. Apart from the high selectivity and sensitivity necessary for volatile organic compound analysis, commercial B-ENs must overcome issues impacting sensor operation and other problems associated with odor localization. The emergence of nanotechnology has provided a novel research concept for addressing these problems. In this work, the structure and operational mechanisms of biomimetic olfactory systems are discussed, with an emphasis on the development and immobilization of materials. Various biosensor applications and current developments are reviewed. Challenges and opportunities for fulfilling the potential of artificial olfactory biohybrid systems in fundamental and practical research are investigated in greater depth" |
| Keywords: | Smell Odorants/analysis *Biosensing Techniques Nanotechnology *Volatile Organic Compounds artificial olfactory system bioelectronic nose biomimicry biosensors volatile organic compounds; |
| Notes: | "MedlineQin, Chuanting Wang, Yi Hu, Jiawang Wang, Ting Liu, Dong Dong, Jian Lu, Yuan eng 2018YFA0901700/National Key R& D Program of China/ 21878173/National Natural Science Foundation of China/ 22278241/National Natural Science Foundation of China/ 2021GQG1016/Tsinghua University/ Research Support, Non-U.S. Gov't Review Germany 2022/12/20 Adv Sci (Weinh). 2023 Feb; 10(5):e2204726. doi: 10.1002/advs.202204726. Epub 2022 Dec 18" |
