| Title: | "Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products" |
| Author(s): | Berlinck RGS; Monteiro AF; Bertonha AF; Bernardi DI; Gubiani JR; Slivinski J; Michaliski LF; Tonon LAC; Venancio VA; Freire VF; |
| Address: | "Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, CP 780, Sao Carlos, CEP 13560-970, SP, Brazil. rgsberlinck@iqsc.usp.br" |
| ISSN/ISBN: | 1460-4752 (Electronic) 0265-0568 (Linking) |
| Abstract: | "Covering: up to 2019The discovery of new bioactive natural products gained momentum during the last few decades, resulting from instrumentation advances, from the expansion of genome mining and regulation, as well as by exploration of untapped biological sources. However, water-soluble, volatile, minor and photosensitive natural products are yet poorly known. This review discusses the literature reporting the isolation strategies for some of these metabolites. Analysis of minor metabolites at sub-milligram level are also presented, since analytical instrumentation enabling structure assignment in minute quantities is now routine. Major trends related to natural products discovery are discussed, under the light of further developments in biodiscovery" |
| Keywords: | Biological Products/chemistry/*isolation & purification/radiation effects Hydrophobic and Hydrophilic Interactions Light Molecular Structure Volatile Organic Compounds/chemistry/isolation & purification/radiation effects; |
| Notes: | "MedlineBerlinck, Roberto G S Monteiro, Afif F Bertonha, Ariane F Bernardi, Darlon I Gubiani, Juliana R Slivinski, Juliano Michaliski, Lamonielli F Tonon, Luciane A C Venancio, Victor A Freire, Vitor F eng Research Support, Non-U.S. Gov't Review England 2019/05/03 Nat Prod Rep. 2019 Jul 1; 36(7):981-1004. doi: 10.1039/c9np00009g. Epub 2019 May 3" |
