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Clin Infect Dis

Title:		"Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study"
Author(s):		Berkhout DJC; van Keulen BJ; Niemarkt HJ; Bessem JR; de Boode WP; Cossey V; Hoogenes N; Hulzebos CV; Klaver E; Andriessen P; van Kaam AH; Kramer BW; van Lingen RA; Schouten A; van Goudoever JB; Vijlbrief DC; van Weissenbruch MM; Wicaksono AN; Covington JA; Benninga MA; de Boer NKH; de Meij TGJ;
Address:		"Department of Pediatric Gastroenterology, Emma Children's Hospital/Academic Medical Center, Amsterdam. Department of Pediatric Gastroenterology, VU University Medical Center, Amsterdam. Neonatal Intensive Care Unit, Maxima Medical Center, Veldhoven. Neonatal Intensive Care Unit, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, The Netherlands. Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium. Neonatal Intensive Care Unit, Beatrix Children's Hospital/University Medical Center Groningen. Neonatal Intensive Care Unit, VU University Medical Center, Amsterdam. Neonatal Intensive Care Unit, Emma Children's Hospital/Academic Medical Center, Amsterdam. Department of Pediatrics, Maastricht University Medical Center, Zwolle. Neonatal Intensive Care Unit, Amalia Children's Centre/Isala, Zwolle. Department of Pediatrics, Emma Children's Hospital/Academic Medical Center, Amsterdam. Department of Pediatrics, VU University Medical Center, Amsterdam. Neonatal Intensive Care Unit, Wilhelmina Children's Hospital/University Medical Center Utrecht, The Netherlands. School of Engineering, University of Warwick, United Kingdom. Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands"
Journal Title:		Clin Infect Dis
Year:		2019
Volume:		68
Issue:		1
Page Number:		70 - 77
DOI:		10.1093/cid/ciy383
ISSN/ISBN:		1537-6591 (Electronic) 1058-4838 (Linking)
Abstract:		"BACKGROUND: The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage. METHODS: In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational age
Keywords:		"Belgium Diagnostic Tests, Routine/*methods Feces/*chemistry Female Humans Infant, Newborn *Infant, Premature Male Neonatal Sepsis/*diagnosis Netherlands Prospective Studies Spectrum Analysis/methods Volatile Organic Compounds/*analysis;"
Notes:		"MedlineBerkhout, Daniel J C van Keulen, Britt J Niemarkt, Hendrik J Bessem, Jet R de Boode, Willem P Cossey, Veerle Hoogenes, Neil Hulzebos, Christiaan V Klaver, Ellen Andriessen, Peter van Kaam, Anton H Kramer, Boris W van Lingen, Richard A Schouten, Aaron van Goudoever, Johannes B Vijlbrief, Daniel C van Weissenbruch, Mirjam M Wicaksono, Alfian N Covington, James A Benninga, Marc A de Boer, Nanne K H de Meij, Tim G J eng Evaluation Study Multicenter Study Research Support, Non-U.S. Gov't 2018/06/23 Clin Infect Dis. 2019 Jan 1; 68(1):70-77. doi: 10.1093/cid/ciy383"