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Curr Biol

Title:		Neuronal perception of the social environment generates an inherited memory that controls the development and generation time of C. elegans
Author(s):		Perez MF; Shamalnasab M; Mata-Cabana A; Della Valle S; Olmedo M; Francesconi M; Lehner B;
Address:		"Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain. Universite de Lyon, ENS de Lyon, Universite de Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 Allee d'Italie, Site Jacques Monod, 69007 Lyon, France. Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, Seville, Spain. Universite de Lyon, ENS de Lyon, Universite de Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 Allee d'Italie, Site Jacques Monod, 69007 Lyon, France. Electronic address: mirko.francesconi@ens-lyon.fr. Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Institucio Catalana de Recerca i Estudis Avancats (ICREA), Pg. Lluis Companys 23, Barcelona 08010, Spain. Electronic address: ben.lehner@crg.eu"
Journal Title:		Curr Biol
Year:		2021
Volume:		20210805
Issue:		19
Page Number:		4256 - 4268
DOI:		10.1016/j.cub.2021.07.031
ISSN/ISBN:		1879-0445 (Electronic) 0960-9822 (Linking)
Abstract:		"An old and controversial question in biology is whether information perceived by the nervous system of an animal can 'cross the Weismann barrier' to alter the phenotypes and fitness of their progeny. Here, we show that such intergenerational transmission of sensory information occurs in the model organism, C. elegans, with a major effect on fitness. Specifically, that perception of social pheromones by chemosensory neurons controls the post-embryonic timing of the development of one tissue, the germline, relative to others in the progeny of an animal. Neuronal perception of the social environment thus intergenerationally controls the generation time of this animal"
Keywords:		Animals *Caenorhabditis elegans/genetics *Caenorhabditis elegans Proteins/genetics Neurons/physiology Perception Social Environment Weismann barrier developmental timing generation time germline intergenerational epigentics pheromones;
Notes:		"MedlinePerez, Marcos Francisco Shamalnasab, Mehrnaz Mata-Cabana, Alejandro Della Valle, Simona Olmedo, Maria Francesconi, Mirko Lehner, Ben eng Research Support, Non-U.S. Gov't England 2021/08/07 Curr Biol. 2021 Oct 11; 31(19):4256-4268.e7. doi: 10.1016/j.cub.2021.07.031. Epub 2021 Aug 5"