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Eur Respir J

Title:		Long-term exposure to close-proximity air pollution and asthma and allergies in urban children
Author(s):		Penard-Morand C; Raherison C; Charpin D; Kopferschmitt C; Lavaud F; Caillaud D; Annesi-Maesano I;
Address:		"UMR S 707, INSERM-UPMC-Paris 6, Medical School St. Antoine, 27 rue de Chaligny, 75571, Paris, Cedex 12, France. celine.morand@polytechnique.org"
Journal Title:		Eur Respir J
Year:		2010
Volume:		20100114
Issue:		1
Page Number:		33 - 40
DOI:		10.1183/09031936.00116109
ISSN/ISBN:		1399-3003 (Electronic) 0903-1936 (Linking)
Abstract:		"The aim of this study was to evaluate the impact of urban air pollution, assessed through reliable indicators of exposure, on asthma and allergies in schoolchildren. A validated dispersion model combining data on traffic conditions, topography, meteorology and background pollution was used to relate 3-yrs averaged concentrations of major urban pollutants at the sites of schools to skin prick tests, exercise-induced asthma and reported asthma and allergies in 6,683 children (9-11 yrs) attending 108 schools randomly selected in six French communities. For the 4,907 children who had resided at their current address for the past 3 yrs, asthma (exercise induced, past year and lifetime) was significantly positively associated with benzene, SO(2), particles with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)), nitrogen oxides (NO(x)) and CO. In the same children, eczema (lifetime and past year) was significantly positively associated with benzene, PM(10), NO(2), NO(x) and CO, lifetime allergic rhinitis with PM(10) and sensitisation to pollens with benzene and PM(10). Among the 2,213 children residing at their current address since birth, the associations persisted for lifetime asthma with benzene (adjusted OR per interquartile range (95% CI) 1.3 (1.0-1.9)) and PM(10 )(1.4 (1.0-2.0)), and for sensitisation to pollens with volatile organic compounds (1.3 (1.0-1.9)) and PM(10) (1.2 (1.0-1.9)). Accurately modelled urban air pollution was associated with some measures of childhood asthma and allergies"
Keywords:		Air Pollution/*adverse effects Asthma/chemically induced/*epidemiology Benzene/adverse effects Carbon Monoxide/adverse effects Child Cross-Sectional Studies *Environmental Exposure Female France/epidemiology Humans Hypersensitivity/*epidemiology/etiology;
Notes:		"MedlinePenard-Morand, C Raherison, C Charpin, D Kopferschmitt, C Lavaud, F Caillaud, D Annesi-Maesano, I eng Research Support, Non-U.S. Gov't England 2010/01/16 Eur Respir J. 2010 Jul; 36(1):33-40. doi: 10.1183/09031936.00116109. Epub 2010 Jan 14"