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Molecules

Title:		Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents
Author(s):		Pena GA; da Costa Lopes AS; de Morais SHS; do Nascimento LD; Dos Santos FRR; da Costa KS; Alves CN; Lameira J;
Address:		"Laboratorio de Planejamento e Desenvolvimento de Farmacos, Federal University of Para, Augusto Correa Street, w/n, Guama, Belem 66075-110, Brazil. Laboratorio de Catalalise e Oleoquimica, Federal University of Para, Augusto Correa Street, w/n, Guama, Belem 66075-110, Brazil. Laboratorio de Quimica Analitica e Ambiental, Federal University of Para, Augusto Correa Street, w/n, Guama, Belem 66075-110, Brazil. Museu Paraense Emilio Goeldi, Laboratorio Adolpho Ducke, Perimetral Avenue, Nuber 1901, Belem 66077-830, Brazil. Instituto de Ciencias da Educacao, Universidade Federal do Oeste do Para, Vera Paz Street, w/n Sale, Santarem 68040-255, Brazil. Laboratorio de Simulacao Computacional, Instituto de Biodiversidade, Universidade Federal do Oeste do Para, Vera Paz Street, w/n Sale, Santarem 68040-255, Brazil"
Journal Title:		Molecules
Year:		2022
Volume:		20220414
Issue:		8
Page Number:		-
DOI:		10.3390/molecules27082519
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alternatives to conventional synthetic repellents due to their interesting residual protection and low toxicity to the environment. However, these compounds have been reported with short shelf life, in part, due to their volatile nature. Nanoencapsulation provides protection, stability, conservation, and controlled release for several compounds. Here, we review the most commonly used polymeric/lipid nanosystems applied in the encapsulation of small organic molecules obtained from essential oils that possess repellent activity, and we also explore the theoretical aspects related to the intermolecular interactions, thermal stability, and controlled release of the nanoencapsulated bioactive compounds"
Keywords:		"*Biological Products/pharmacology Delayed-Action Preparations *Insect Repellents/chemistry/pharmacology *Oils, Volatile/chemistry/pharmacology Polymers controlled release essential oils intermolecular interactions nanoencapsulation nanosystems natural rep;"
Notes:		"MedlinePena, Gueive Astur da Costa Lopes, Anna Sylmara de Morais, Sylvano Heleno Salgado do Nascimento, Lidiane Diniz Dos Santos, Fabio Rogerio Rodrigues da Costa, Kaue Santana Alves, Claudio Nahum Lameira, Jeronimo eng 88882.466102/2019-01/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ Review Switzerland 2022/04/24 Molecules. 2022 Apr 14; 27(8):2519. doi: 10.3390/molecules27082519"