| Title: | Aggregating exposures & cumulating risk for semivolatile organic compounds: A review |
| Author(s): | Pelletier M; Bonvallot N; Glorennec P; |
| Address: | "EHESP-School of Public Health, Sorbonne Paris Cite, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France. EHESP-School of Public Health, Sorbonne Paris Cite, Rennes, France; INSERM-U1085, Irset-Research Institute for Environmental and Occupational Health, Rennes, France. Electronic address: philippe.glorennec@ehesp.fr" |
| DOI: | 10.1016/j.envres.2017.06.022 |
| ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Linking) |
| Abstract: | "Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure. Preferential routes and sources of exposure are influenced by SVOC physical-chemical properties such as vapor pressure. The cumulative risk approach for contaminants is based on dose addition. Simple sum of hazard quotient (Hazard Index: HI) is the most commonly used cumulative risk assessment approach, while Relative Potency Factor (RPF) appeared to the best suited - although this calls for a level of toxicological information that limits the number of compounds that can be studied simultaneously. Where both were performed, moving from HI to more refined approach produced similar results. In conclusion, both approaches - exposure aggregation and cumulative risk - rely on simple assumptions. Nevertheless, they allow uncertainty to be reduced, in comparison with source-by-source or chemical-by-chemical approaches" |
| Keywords: | *Environmental Exposure Environmental Monitoring Environmental Pollutants/*toxicity Humans Risk Assessment Volatile Organic Compounds/*toxicity Chemical Contaminants Cumulative risk assessment Environmental exposure Exposure pathway Health Mixture; |
| Notes: | "MedlinePelletier, Maud Bonvallot, Nathalie Glorennec, Philippe eng Research Support, Non-U.S. Gov't Review Netherlands 2017/07/22 Environ Res. 2017 Oct; 158:649-659. doi: 10.1016/j.envres.2017.06.022. Epub 2017 Jul 18" |
