| Title: | Biological Activity of Humulus Lupulus (L.) Essential Oil and Its Main Components Against Sitophilus granarius (L.) |
| Author(s): | Paventi G; de Acutis L; De Cristofaro A; Pistillo M; Germinara GS; Rotundo G; |
| Address: | "Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, via de Sanctis, 86100 Campobasso, Italy. Department of Agricultural, Environmental and Food Sciences, University of Molise, via de Sanctis, 86100 Campobasso, Italy. Department of the Sciences of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy" |
| ISSN/ISBN: | 2218-273X (Electronic) 2218-273X (Linking) |
| Abstract: | "Besides its use in the brewing industry, hop cones appear as a powerful source of biologically active compounds, already checked for their putative anticancer, antimicrobial, and other bioactivities. Conversely, hop use in pest control remains to date under-investigated. Therefore, the biological activity of hop essential oil (EO) and its main constituents was investigated here against Sitophilus granarius. Adult contact toxicity was found 24 h after treatment with hop EO (LD(50)/LD(90) 13.30/40.23 microg/adult), and its three most abundant components, alpha-humulene, beta-myrcene, and beta-caryophyllene (LD(50)/LD(90) 41.87/73.51, 75.91/126.05, and 138.51/241.27 microg/adult, respectively); negligible variations at 48 h, except for alpha-humulene (LD(50)/LD(90) 26.83/49.49 microg/adult), were found. The fumigant toxicity of the EO and terpenes was also checked: in the absence of wheat grains, beta-myrcene showed the highest inhalation toxicity (LC(50)/LC(90) 72.78/116.92 mg/L air), whereas alpha-humulene, beta-caryophyllene, and the EO induced similar values (LC(50)/LC(90) about 130/200 mg/L air); with the exception for EO, the wheat presence increased (30-50%) LC(50)/LC(90) values. Moreover, EO and terpenes were perceived by insect antennae and elicited repellent activity. Only beta-caryophyllene showed an anticholinesterase effect, this suggesting that different mechanisms of action should be responsible for hop EO toxicity. Therefore, hop EO appears suitable for developing control means against this pest" |
| Keywords: | "Animals Female Humulus/*chemistry Insect Repellents/*toxicity Insecticides/chemistry/*toxicity Male Oils, Volatile/chemistry/*toxicity Pest Control Terpenes/chemistry/toxicity Weevils/*drug effects/physiology acetylcholinesterase botanical insecticides el;" |
| Notes: | "MedlinePaventi, Gianluca de Acutis, Laura De Cristofaro, Antonio Pistillo, Marco Germinara, Giacinto S Rotundo, Giuseppe eng Programma di Sviluppo Rurale (PSR) 2007-2013, Measure 124, Project title: Innovazione nella filiera ortofrutticola pugliese della Daunia - Innovazioni Biotecniche per la Produzione Eco-sostenibile del Pomodoro da Industria 'POMINNOVA'/Regione Puglia/International Department of Medicine and Health Sciences 'V. Tiberio' internal fund/University of Molise/International Research Support, Non-U.S. Gov't Switzerland 2020/07/30 Biomolecules. 2020 Jul 25; 10(8):1108. doi: 10.3390/biom10081108" |
