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Lipids

Title:		An essential fungal growth factor derived from ergosterol: a new end product of sterol biosynthesis in fungi?
Author(s):		Parks LW; Rodriguez RJ; Low C;
Address:
Journal Title:		Lipids
Year:		1986
Volume:		21
Issue:		1
Page Number:		89 - 91
DOI:		10.1007/BF02534308
ISSN/ISBN:		0024-4201 (Print) 0024-4201 (Linking)
Abstract:		"Concentrations of ergosterol as low as 1.2 mM are effective in satisfying the essential high specificity microrequirement for C5,6 unsaturated sterol in yeast. In a sterol auxotroph supplemented with saturated sterol (cholestanol), aqueous extracts of yeast provide a growth factor that eliminates the ergosterol microrequirement. The factor is easily differentiated from ergosterol by solubility, thermostability, and thin layer and liquid chromatography and is functional at levels equivalent to those of vitamins, hormones and pheromones"
Keywords:		"Cholestanols/pharmacology Chromatography, High Pressure Liquid Ergosterol/*metabolism *Growth Substances Kinetics Saccharomyces cerevisiae/drug effects/*growth & development Sterols/*biosynthesis/isolation & purification;"
Notes:		"MedlineParks, L W Rodriguez, R J Low, C eng AM-05190/AM/NIADDK NIH HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1986/01/01 Lipids. 1986 Jan; 21(1):89-91. doi: 10.1007/BF02534308"