| Title: | N-Triflyl Phosphoric Triamide: A High-Performance Purely Organic Trifurcate Quartz Crystal Microbalance Sensor for Chemical Warfare Agent |
| Author(s): | Park JH; Song SG; Shin MH; Song C; Bae HY; |
| Address: | "Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea" |
| DOI: | 10.1021/acssensors.1c02715 |
| ISSN/ISBN: | 2379-3694 (Electronic) 2379-3694 (Linking) |
| Abstract: | "G-, V-, and A-series nerve agents are extremely toxic organophosphorus chemical warfare agents (CWAs) that incorporate P horizontal lineO functional groups. Their colorless, tasteless, and odorless nature makes rapid and efficient detection challenging. Here, we report an unprecedented N-triflyl phosphoric triamide (N-TPT) receptor, which is a new class of triple hydrogen bonding donor molecular sensors for CWA recognition via noncovalent host-guest-type interactions. The highly robust trifurcate structures were designed based on density functional theory (DFT) computations and synthesized from N-triflyl phosphorimidoyl trichloride by simple stepwise processes. Quartz crystal microbalance (QCM) analysis allowed robust detection of typical CWA simulants, such as dimethyl methylphosphonate. The concentration-dependent QCM profiles were fitted with the Sips isotherm model, revealing that the thermodynamic parameters of the binding behaviors are roughly correlated with the calculated results. Developed N-TPT receptors show higher binding abilities than previously reported receptors and reasonable selectivity over other volatile compounds" |
| Keywords: | *Chemical Warfare Agents/analysis *Quartz Crystal Microbalance Techniques/methods N-triflyl phosphoric triamide (N-TPT) chemical warfare agent (CWA) hydrogen bonding donor quartz crystal microbalance (QCM) sensors; |
| Notes: | "MedlinePark, Jin Hyun Song, Sun Gu Shin, Myoung Hyeon Song, Changsik Bae, Han Yong eng Research Support, Non-U.S. Gov't 2022/02/05 ACS Sens. 2022 Feb 25; 7(2):423-429. doi: 10.1021/acssensors.1c02715. Epub 2022 Feb 4" |
