| Title: | CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-beta expression |
| Author(s): | Park J; Oh H; Kim DY; Cheon Y; Park YJ; Hwang H; Neal SJ; Dar AR; Butcher RA; Sengupta P; Kim DW; Kim K; |
| Address: | "Department of Brain and Cognitive Sciences, DGIST, Daegu, Republic of Korea. Department of Biochemistry, Yonsei University, Seoul, Republic of Korea. Department of Neuroscience, SUNY Upstate Medical University, Syracuse, New York, United States of America. Department of Chemistry, University of Florida, Gainesville, Florida, United States of America. Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America. Korea Brain Research Institute (KBRI), Daegu, Republic of Korea" |
| DOI: | 10.1371/journal.pgen.1009678 |
| ISSN/ISBN: | 1553-7404 (Electronic) 1553-7390 (Print) 1553-7390 (Linking) |
| Abstract: | "Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a novel role of cAMP response element binding protein (CREB)-encoding crh-1 gene in developmental polyphenism of C. elegans. Under conditions that promote normal development in wild-type animals, crh-1 mutants inappropriately form transient pre-dauer (L2d) larvae and express the L2d marker gene. L2d formation in crh-1 mutants is specifically induced by the ascaroside pheromone ascr#5 (asc-omegaC3; C3), and crh-1 functions autonomously in the ascr#5-sensing ASI neurons to inhibit L2d formation. Moreover, we find that CRH-1 directly binds upstream of the daf-7 TGF-beta locus and promotes its expression in the ASI neurons. Taken together, these results provide new insight into how animals alter their developmental programs in response to environmental changes" |
| Keywords: | "Adaptation, Physiological/genetics Animals Caenorhabditis elegans/genetics Caenorhabditis elegans Proteins/genetics/*metabolism Cell Cycle Cell Growth Processes Cyclic AMP Response Element-Binding Protein/*metabolism/physiology Gene Expression/genetics Ge;neuroscience;" |
| Notes: | "MedlinePark, JiSoo Oh, Hyekyoung Kim, Do-Young Cheon, YongJin Park, Yeon-Ji Hwang, Hyeonjeong Neal, Scott J Dar, Abdul Rouf Butcher, Rebecca A Sengupta, Piali Kim, Dae-Won Kim, Kyuhyung eng K99 GM087533/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ R00 GM087533/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2021/07/15 PLoS Genet. 2021 Jul 14; 17(7):e1009678. doi: 10.1371/journal.pgen.1009678. eCollection 2021 Jul" |
