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ACS Sens

Title:		Ionic Liquid-Carbon Nanotube Sensor Arrays for Human Breath Related Volatile Organic Compounds
Author(s):		Park CH; Schroeder V; Kim BJ; Swager TM;
Address:		"Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States. Department of Chemical and Biomolecular Engineering , Korea Advanced Institute of Science and Technology (KAIST) , Daejeon , 34141 Republic of Korea"
Journal Title:		ACS Sens
Year:		2018
Volume:		20181031
Issue:		11
Page Number:		2432 - 2437
DOI:		10.1021/acssensors.8b00987
ISSN/ISBN:		2379-3694 (Electronic) 2379-3694 (Linking)
Abstract:		"High sensitivity, selectivity, and stability are key requirements for carbon nanotube (CNT)-based sensors to realize their full potential in applications ranging from chemical warfare agent detection to disease diagnostics. Herein we demonstrate the sensing of volatile organic compounds (VOCs) relevant to human diseases using an array of chemiresistive carbon nanotube (CNT)-based sensors functionalized with ionic liquids (ILs). The ILs are fluid at ambient temperature and were selected to produce a discriminating sensor array capable of the gas-phase detection of human disease-related VOCs. We find that sensor arrays consisting of imidazolium-based ILs with different substituents and counterions provide selective responses for known biomarkers of infectious diseases of the lungs. Specifically, the sensors discriminate the various volatile biomarkers for tuberculosis based on their polarity, solubility, and chemical affinities. In addition to selectivity, the sensors also show a high level of reversibility and promising long-term stability, which renders them to be suitable candidates for practical applications in breath analysis"
Keywords:		"Biomarkers/analysis Breath Tests/methods Humans Imidazoles/chemical synthesis/chemistry Ionic Liquids/chemical synthesis/*chemistry Nanotubes, Carbon/*chemistry Volatile Organic Compounds/*analysis breath carbon nanotubes chemiresistor gas sensor array io;"
Notes:		"MedlinePark, Chan Ho Schroeder, Vera Kim, Bumjoon J Swager, Timothy M eng Research Support, Non-U.S. Gov't 2018/11/01 ACS Sens. 2018 Nov 26; 3(11):2432-2437. doi: 10.1021/acssensors.8b00987. Epub 2018 Oct 31"