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Vopr Med Khim

Title:		"[Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A]"
Author(s):		Panova NG; Veselovskaia NV; Medvedev AE;
Address:		"NII of Biomedical Chemistry RAMN, Moscow"
Journal Title:		Vopr Med Khim
Year:		1997
Volume:		43
Issue:		3
Page Number:		172 - 176
DOI:
ISSN/ISBN:		0042-8809 (Print) 0042-8809 (Linking)
Abstract:		Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formation of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol
Keywords:		Adrenergic alpha-Antagonists/pharmacology Animals Brain/drug effects/*metabolism Cattle Gas Chromatography-Mass Spectrometry *Isatin Male Monoamine Oxidase Inhibitors/*pharmacology NAD/pharmacology Phenylethyl Alcohol/*analogs & derivatives/metabolism Phe;
Notes:		"MedlinePanova, N G Veselovskaia, N V Medvedev, A E rus English Abstract Russia (Federation) 1997/05/01 Vopr Med Khim. 1997 May-Jun; 43(3):172-6"