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Environ Pollut

Title:		Assessment of exposure to volatile organic compounds through urinary concentrations of their metabolites in pet dogs and cats from the United States
Author(s):		Pal VK; Kannan K;
Address:		"Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, United States. Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, United States. Electronic address: kurunthachalam.kannan@nyulangone.org"
Journal Title:		Environ Pollut
Year:		2023
Volume:		20221103
Issue:		Pt 2
Page Number:		120576 -
DOI:		10.1016/j.envpol.2022.120576
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"Volatile organic compounds (VOCs) are ubiquitous environmental pollutants, exposure to which is associated with birth defects, neurocognitive and reproductive impairments, and cancer. Little is known, however, about VOC exposure in pet dogs and cats, which represent sentinels for human exposure as well as having value as companion animals. In this study, we determined 38 VOC metabolites (VOCMs) in urine samples collected from 47 dogs and 42 cats from the Albany area of New York State. Seventeen (in cats) to twenty (in dogs) VOCMs were found at detection frequencies (DFs) above 60%. The creatinine-adjusted geometric mean (GM) concentrations of individual VOCMs ranged from 5.43 (EMA) to 761 mug/g (3HPMA) in dog urine and 0.824 (SBMA) to 278 mug/g (ATCA) in cat urine. The summation operator20 VOCM concentration in dog urine was 2280 mug/g (geometric mean) and the summation operator17 VOCM concentration in cat urine was 847 mug/g. Eight individual VOCMs were significantly more abundant in dog than in cat urine, and the urinary concentrations of several VOCMs in dogs were comparable to those reported for human tobacco smokers. Metabolites of acrolein accounted for 43% of summation operator20 VOCM concentration in dogs, whereas those of cyanide and benzene accounted for 60% of summation operator17 VOCM concentration in cats. Based on acrylamide exposure doses, calculated hazard quotients were above 1 in 77% of dogs and 50% of cats studied, and cancer risk values (using a benchmark of 10(-6)) from exposure to acrylamide exceeded 1 for all dogs and cats. This is the first study to report VOCM concentrations in urine collected from pet dogs and cats and highlights the need to identify sources and health implications of VOCs exposure in these animals"
Keywords:		Humans Cats Dogs United States Animals *Volatile Organic Compounds *Cat Diseases *Dog Diseases New York Acrylamides Benzene Cancer Sentinels VOC metabolites;
Notes:		"MedlinePal, Vineet Kumar Kannan, Kurunthachalam eng England 2022/11/07 Environ Pollut. 2023 Jan 1; 316(Pt 2):120576. doi: 10.1016/j.envpol.2022.120576. Epub 2022 Nov 3"