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J Cyst Fibros

Title:		Exhaled molecular profiles in the assessment of cystic fibrosis and primary ciliary dyskinesia
Author(s):		Paff T; van der Schee MP; Daniels JM; Pals G; Postmus PE; Sterk PJ; Haarman EG;
Address:		"Department of Pulmonary Diseases, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. t.paff@vumc.nl"
Journal Title:		J Cyst Fibros
Year:		2013
Volume:		20130127
Issue:		5
Page Number:		454 - 460
DOI:		10.1016/j.jcf.2012.12.010
ISSN/ISBN:		1873-5010 (Electronic) 1569-1993 (Linking)
Abstract:		"BACKGROUND: Early diagnosis and monitoring of disease activity are essential in cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). We aimed to establish exhaled molecular profiles as the first step in assessing the potential of breath analysis. METHODS: Exhaled breath was analyzed by electronic nose in 25 children with CF, 25 with PCD and 23 controls. Principle component reduction and canonical discriminant analysis were used to construct internally cross-validated ROC curves. RESULTS: CF and PCD patients had significantly different breath profiles when compared to healthy controls (CF: sensitivity 84%, specificity 65%; PCD: sensitivity 88%, specificity 52%) and from each other (sensitivity 84%, specificity 60%). Patients with and without exacerbations had significantly different breath profiles (CF: sensitivity 89%, specificity 56%; PCD: sensitivity 100%, specificity 90%). CONCLUSION: Exhaled molecular profiles significantly differ between patients with CF, PCD and controls. The eNose may have potential in disease monitoring based on the influence of exacerbations on the VOC-profile"
Keywords:		"Adolescent Breath Tests Case-Control Studies Child Child, Preschool Cross-Sectional Studies Cystic Fibrosis/*diagnosis/microbiology Female Humans Infant Kartagener Syndrome/*diagnosis/microbiology Male Cystic fibrosis Electronic nose Exhaled breath Primar;"
Notes:		"MedlinePaff, T van der Schee, M P Daniels, J M A Pals, G Postmus, P E Sterk, P J Haarman, E G eng Research Support, Non-U.S. Gov't Netherlands 2013/01/31 J Cyst Fibros. 2013 Sep; 12(5):454-60. doi: 10.1016/j.jcf.2012.12.010. Epub 2013 Jan 27"