| Title: | "Natural essential oil mix of sweet orange peel, cumin, and allspice elicits anti-inflammatory activity and pharmacological safety similar to non-steroidal anti-inflammatory drugs" |
| Author(s): | Padilla-Camberos E; Sanchez-Hernandez IM; Torres-Gonzalez OR; Gallegos-Ortiz MDR; Mendez-Mona AL; Baez-Moratilla P; Flores-Fernandez JM; |
| Address: | "Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. (CIATEJ), Guadalajara, Jalisco 44270, Mexico. Division of Engineering in Food Industries, Tecnologico de Estudios Superiores de Villa Guerrero, La Finca, State of Mexico 61763, Mexico. Department of Research and Innovation, Universidad Tecnologica de Oriental, Oriental, Puebla 75020, Mexico. Department of Biochemistry & Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, Edmonton, AB T6G 2M8, Canada" |
| DOI: | 10.1016/j.sjbs.2022.03.002 |
| ISSN/ISBN: | 1319-562X (Print) 2213-7106 (Electronic) 2213-7106 (Linking) |
| Abstract: | "An inflammation response occurs when the body reacts to exogenous and endo enous noxious stimuli, and it helps the body respond to infection and repair tissues, adapt to stress, and remove dead or damaged cells. Anti-inflammatory drugs such as non-steroidal anti-inflammatory drugs are traditionally used to treat inflammation; however, these drugs often cause negative side effects. For this reason, developing and establishing effective alternative medicines for treating many chronic diseases with underlying inflammation is critically dependent on the identification of new organic molecules and bioactive substances. Aromatic and volatile compounds found in essential oils isolated from Pimenta dioica (allspice), Cuminum cyminum (cumin), and Citrus sinensis (sweet orange) are a source of bioactive compounds. Allspice essential oil reduces ear inflammation more than 65% and the anti-inflammatory activity of allspice essential oil is enhanced when combined with sweet orange peel and cumin essential oils, resulting in the reduction of edema inflammation by more than 85%, similar to indomethacin. As an alternative to anti-inflammatory treatment, essential oil mix is pharmacologically safe as it is neither toxic nor mutagenic" |
| Keywords: | Anti-inflammatory activity Citrus sinensis (sweet orange) Cuminum cyminum (cumin) Ear edema Essential oil Mutagenic NSAIDs Pimenta dioica (allspice); |
| Notes: | "PubMed-not-MEDLINEPadilla-Camberos, Eduardo Sanchez-Hernandez, Ivan Moises Torres-Gonzalez, Omar Ricardo Gallegos-Ortiz, Maria Del Rosario Mendez-Mona, Ana Laura Baez-Moratilla, Pedro Flores-Fernandez, Jose Miguel eng Saudi Arabia 2022/07/19 Saudi J Biol Sci. 2022 May; 29(5):3830-3837. doi: 10.1016/j.sjbs.2022.03.002. Epub 2022 Mar 5" |
