| Title: | "Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic" |
| Address: | "Department of Biological Sciences and Molecular Biology and Genetics, Middle East Technical University, 06800 Ankara, Turkey. Electronic address: ozcengiz@metu.edu.tr. Marmara University, Research and Training Hospital, Division of Pediatric Allergy and Immunology, 34899 Istanbul, Turkey" |
| DOI: | 10.1016/j.nbt.2015.01.006 |
| ISSN/ISBN: | 1876-4347 (Electronic) 1871-6784 (Linking) |
| Abstract: | "Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of l-alanine residue at the N terminus and a non-proteinogenic amino acid, l-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme l-amino acid ligase (Lal) are also discussed" |
| Keywords: | "Anti-Bacterial Agents/*biosynthesis/*chemistry/isolation & purification Bacillus subtilis/*physiology Dipeptides/biosynthesis/genetics Gene Expression Regulation, Bacterial/*physiology Models, Biological;" |
| Notes: | "MedlineOzcengiz, Gulay Ogulur, Ismail eng Review Netherlands 2015/02/04 N Biotechnol. 2015 Dec 25; 32(6):612-9. doi: 10.1016/j.nbt.2015.01.006. Epub 2015 Jan 30" |
