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Science

Title:		Adrenal-mediated endogenous metabolites inhibit puberty in female mice
Author(s):		Novotny M; Jemiolo B; Harvey S; Wiesler D; Marchlewska-Koj A;
Address:
Journal Title:		Science
Year:		1986
Volume:		231
Issue:		4739
Page Number:		722 - 725
DOI:		10.1126/science.3945805
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored"
Keywords:		Adrenal Glands/*physiology Animals Female Ketones/urine Mice Ovary/physiology Pentanols/urine Pheromones/physiology/urine Pyrazines/urine *Sexual Maturation;
Notes:		"MedlineNovotny, M Jemiolo, B Harvey, S Wiesler, D Marchlewska-Koj, A eng 1986/02/14 Science. 1986 Feb 14; 231(4739):722-5. doi: 10.1126/science.3945805"