| Title: | In vitro effects of pollutants from particulate and volatile fractions of air samples-day and night variability |
| Author(s): | Novak J; Giesy JP; Klanova J; Hilscherova K; |
| Address: | "Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. novakj@recetox.muni.cz" |
| Journal Title: | Environ Sci Pollut Res Int |
| DOI: | 10.1007/s11356-013-1726-6 |
| ISSN/ISBN: | 1614-7499 (Electronic) 0944-1344 (Linking) |
| Abstract: | "Chemicals in air were characterized for potential interference with signaling of estrogen, androgen, and arylhydrocarbon (AhR) receptors, which are known to play an important role in endocrine-disruptive changes in vivo. Previously, effects of this type have been studied mainly in particulate matter in the ambient air from various localities. In this study, both volatile and particulate fractions of air from three sites in Banja Luka region (Bosnia and Herzegovina) were investigated to describe the distribution of endocrine-disrupting contaminants on a small spatial scale. Circadian variability of air pollution was investigated by collecting samples during both day and night. Air samples collected from urban localities at night were more potent in producing the AhR-mediated effects than those collected during daytime. This trend was not observed at the reference rural location. None of the samples showed significant estrogenic or androgenic activity. On the other hand, anti-androgenicity was detected in both particulate and vapor phases, while anti-estrogenicity was detected only in the particulate fraction of air from all localities. The AhR-mediated potencies of samples were associated primarily with non-persistent compounds. Based on the concentrations of 28 individual compounds, PAHs accounted for approximately 30 % of the AhR-mediated potency determined by the bioassay. The results show that there can be a significant difference between levels of bioactive compounds in air between daytime and nighttime" |
| Keywords: | "Air/*analysis Air Pollutants/*chemistry Animals Biological Assay Cell Line, Tumor Circadian Rhythm Endocrine Disruptors Particulate Matter/*chemistry Principal Component Analysis Rats Receptors, Androgen Receptors, Estrogen Signal Transduction Volatile Or;" |
| Notes: | "MedlineNovak, Jiri Giesy, John P Klanova, Jana Hilscherova, Klara eng Research Support, Non-U.S. Gov't Germany 2013/04/25 Environ Sci Pollut Res Int. 2013 Sep; 20(9):6620-7. doi: 10.1007/s11356-013-1726-6. Epub 2013 Apr 24" |
