| Title: | "Effects of continuous low dose infusion of lipopolysaccharide on inflammatory responses, milk production and milk quality in dairy cows" |
| Author(s): | Ning LT; Dong GZ; Ao C; Zhang DG; Erdene K; Zhang FQ; Wen J; Zhang TL; |
| Address: | "Key Laboratory of Grass and Herbivores of Chongqing, College of Animal Science and Technology, Southwest University, Chongqing, China. College of Animal Science, Inner Mongolia Agricultural University, Hohhot, China" |
| Journal Title: | J Anim Physiol Anim Nutr (Berl) |
| ISSN/ISBN: | 1439-0396 (Electronic) 0931-2439 (Linking) |
| Abstract: | "The objective of this study was to evaluate the effects of continuous low dose infusion of lipopolysaccharide (LPS) on inflammatory responses and milk production and quality in lactating dairy cows. Eight Holstein cows were assigned to two treatments in a cross-over experimental design. Cows were infused intravenously either with saline solution or with saline solution containing LPS from Escherichia coli O111:B4 at a dose of 0.01 mug LPS/kg body weight for approximately 6 hr each day during a seven-day trial. The clinical symptoms and milk production performance were observed. Milk samples were analysed for conventional components, fatty acids and amino acids. And jugular vein and mammary vein plasma samples were analysed for concentrations of cytokines and acute phase proteins. LPS infusion decreased feed intake and milk yield. An increase in body temperature was observed after LPS infusion. LPS infusion also increased plasma concentrations of interleukin-1beta, serum amyloid A, LPS-binding protein, C-reactive protein and haptoglobin. LPS infusion decreased the contents of some fatty acids, such as C17:1, C18:0, C18:1n9 (trans) and C18:2n6 (trans), and most amino acids except for methionine, threonine, histidine, cysteine, tyrosine and proline in the milk. The results indicated that a continued low dose infusion of LPS can induce an inflammatory response, decrease milk production and reduce milk quality" |
| Keywords: | Acute-Phase Proteins/metabolism Animals Cattle Cattle Diseases/*chemically induced/metabolism Cross-Over Studies Cytokines/blood/genetics/metabolism Female Gene Expression Regulation/drug effects Inflammation/chemically induced/metabolism/*veterinary Lact; |
| Notes: | "MedlineNing, L T Dong, G Z Ao, C Zhang, D G Erdene, K Zhang, F Q Wen, J Zhang, T L eng Randomized Controlled Trial Germany 2017/05/16 J Anim Physiol Anim Nutr (Berl). 2018 Feb; 102(1):e262-e269. doi: 10.1111/jpn.12737. Epub 2017 May 15" |
