| Title: | Altered social behavior in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice |
| Author(s): | Nicot A; Otto T; Brabet P; Dicicco-Bloom EM; |
| Address: | "Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA" |
| DOI: | 10.1523/JNEUROSCI.1910-04.2004 |
| ISSN/ISBN: | 1529-2401 (Electronic) 0270-6474 (Print) 0270-6474 (Linking) |
| Abstract: | "The olfactory bulb plays a critical role in odor discrimination and in processing olfactory cues controlling social behavior in mammals. Given that the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1) is highly expressed in the olfactory bulb, we examined its role in regulating olfaction and social investigation. We found that olfactory detection of nonsocial stimuli was similar in PAC1-deficient mice and wild-type (WT) littermates. In contrast, PAC1-deficient mice displayed markedly abnormal social behaviors. PAC1-deficient mice exhibited a faster decrease in social investigation after repeated exposure to social cues or ovariectomized female urine compared with WT mice. Moreover, PAC1-deficient females exhibited delayed affiliative behavior when housed with novel males, and PAC1-deficient males displayed excessive sexual mounting toward both females and males as well as reduced aggression and increased licking and grooming toward intruder males. In aggregate, these results uncover PAC1 signaling as an important factor in the development and/or functioning of neural pathways associated with pheromone processing and the regulation of social interactions in mice. In turn, these studies raise the potential clinical relevance of PACAP signaling dysfunctions in neuropsychiatric disorders characterized by social reciprocity impairments such as autism spectrum disorders" |
| Keywords: | "Aggression Animals Behavior, Animal Bromodeoxyuridine/analysis Female Habituation, Psychophysiologic Humans Lateral Ventricles/cytology Male Mice Mice, Knockout Odorants Receptors, Cell Surface/genetics/*physiology Receptors, Pituitary Adenylate Cyclase-A;" |
| Notes: | "MedlineNicot, Arnaud Otto, Timothy Brabet, Philippe Dicicco-Bloom, Emanuel M eng R01 NS032401/NS/NINDS NIH HHS/ NS32401/NS/NINDS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2004/10/08 J Neurosci. 2004 Oct 6; 24(40):8786-95. doi: 10.1523/JNEUROSCI.1910-04.2004" |
