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J Neurochem

Title:		Conservation of the function counts: homologous neurons express sequence-related neuropeptides that originate from different genes
Author(s):		Neupert S; Huetteroth W; Schachtner J; Predel R;
Address:		"Institute of Zoology, Friedrich-Schiller, University of Jena, Jena, Germany. mail@susanne-neupert.de"
Journal Title:		J Neurochem
Year:		2009
Volume:		20090827
Issue:		3
Page Number:		757 - 765
DOI:		10.1111/j.1471-4159.2009.06361.x
ISSN/ISBN:		1471-4159 (Electronic) 0022-3042 (Linking)
Abstract:		"By means of single-cell matrix assisted laser desorption/ionization time-of-flight mass spectrometry, we analysed neuropeptide expression in all FXPRLamide/pheromone biosynthesis activating neuropeptide synthesizing neurons of the adult tobacco hawk moth, Manduca sexta. Mass spectra clearly suggest a completely identical processing of the pheromone biosynthesis activating neuropeptide-precursor in the mandibular, maxillary and labial neuromeres of the subesophageal ganglion. Only in the pban-neurons of the labial neuromere, products of two neuropeptide genes, namely the pban-gene and the capa-gene, were detected. Both of these genes expressed, amongst others, sequence-related neuropeptides (extended WFGPRLamides). We speculate that the expression of the two neuropeptide genes is a plesiomorph character typical of moths. A detailed examination of the neuroanatomy and the peptidome of the (two) pban-neurons in the labial neuromere of moths with homologous neurons of different insects indicates a strong conservation of the function of this neuroendocrine system. In other insects, however, the labial neurons either express products of the fxprl-gene or products of the capa-gene. The processing of the respective genes is reduced to extended WFGPRLamides in each case and yields a unique peptidome in the labial cells. Thus, sequence-related messenger molecules are always produced in these cells and it seems that the respective neurons recruited different neuropeptide genes for this motif"
Keywords:		"Animals Ganglia, Invertebrate/cytology Insect Proteins/*genetics/*metabolism Manduca/anatomy & histology/*genetics/metabolism Molecular Sequence Data Neurons/*metabolism Neuropeptides/*genetics/*metabolism Protein Structure, Tertiary/genetics Spectrometry;"
Notes:		"MedlineNeupert, Susanne Huetteroth, Wolf Schachtner, Joachim Predel, Reinhard eng Research Support, Non-U.S. Gov't England 2009/08/29 J Neurochem. 2009 Nov; 111(3):757-65. doi: 10.1111/j.1471-4159.2009.06361.x. Epub 2009 Aug 27"