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BMC Vet Res

Title:		Novel biotechnological approaches for monitoring and immunization against resistant to antibiotics Escherichia coli and other pathogenic bacteria
Author(s):		Belizario JE; Sircili MP;
Address:		"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1524, Sao Paulo, SP, CEP 05508-900, Brazil. josebelizario223@gmail.com. Laboratory of Genetics, Butantan Institute, Av. Vital Brazil, 1500, Sao Paulo, SP, CEP 05503-900, Brazil"
Journal Title:		BMC Vet Res
Year:		2020
Volume:		20201102
Issue:		1
Page Number:		420 -
DOI:		10.1186/s12917-020-02633-8
ISSN/ISBN:		1746-6148 (Electronic) 1746-6148 (Linking)
Abstract:		"The application of next-generation molecular, biochemical and immunological methods for developing new vaccines, antimicrobial compounds, probiotics and prebiotics for zoonotic infection control has been fundamental to the understanding and preservation of the symbiotic relationship between animals and humans. With increasing rates of antibiotic use, resistant bacterial infections have become more difficult to diagnose, treat, and eradicate, thereby elevating the importance of surveillance and prevention programs. Effective surveillance relies on the availability of rapid, cost-effective methods to monitor pathogenic bacterial isolates. In this opinion article, we summarize the results of some research program initiatives for the improvement of live vaccines against avian enterotoxigenic Escherichia coli using virulence factor gene deletion and engineered vaccine vectors based on probiotics. We also describe methods for the detection of pathogenic bacterial strains in eco-environmental headspace and aerosols, as well as samples of animal and human breath, based on the composition of volatile organic compounds and fatty acid methyl esters. We explain how the introduction of these low-cost biotechnologies and protocols will provide the opportunity to enhance co-operation between networks of resistance surveillance programs and integrated routine workflows of veterinary and clinical public health microbiology laboratories"
Keywords:		"Animals Anti-Bacterial Agents/pharmacology Bacteria/immunology Bacterial Infections/immunology *Biotechnology Chickens *Drug Resistance, Bacterial Enterotoxigenic Escherichia coli/genetics/*immunology Escherichia coli Infections/immunology/veterinary Esch;"
Notes:		"MedlineBelizario, Jose E Sircili, Marcelo P eng 486048/2011 and 312206/2016-0/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ 2012/02497-7, 2014/20847-0/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ 10/06707-0/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ England 2020/11/04 BMC Vet Res. 2020 Nov 2; 16(1):420. doi: 10.1186/s12917-020-02633-8"