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Arch Bronconeumol

Title:		Influence of Chronic Obstructive Pulmonary Disease on Volatile Organic Compounds in Patients with Non-Small Cell Lung Cancer
Author(s):		Munoz-Lucas MA; Jareno-Esteban J; Gutierrez-Ortega C; Lopez-Guijarro P; Collado-Yurrita L; Quintana-Diaz M; Callol-Sanchez L;
Address:		"Unidad de Apoyo a la Investigacion, Jefatura de Docencia e Investigacion, Hospital Central de la Defensa, Madrid, Spain. Electronic address: mmunozlucas@yahoo.es. Servicio de Neumologia, Hospital Central de la Defensa, Universidad de Alcala de Henares (Madrid), Spain. Unidad de Apoyo a la Investigacion, Servicio de Medicina Preventiva Hospital Central de la Defensa Gomez Ulla Hospital Central de la Defensa, Madrid, Spain. Ministerio de Defensa, Madrid, Spain. Departamento Medicina, Universidad Complutense de Madrid, Madrid, Spain. Departamento Medicina, Universidad Autonoma de Madrid, Servicio de Medicina Intensiva del Hospital Universitario La Paz, Madrid, Spain"
Journal Title:		Arch Bronconeumol
Year:		2020
Volume:		20201105
Issue:		12
Page Number:		801 - 805
DOI:		10.1016/j.arbr.2020.10.004
ISSN/ISBN:		1579-2129 (Electronic) 0300-2896 (Linking)
Abstract:		"INTRODUCTION: The etiology of lung cancer is multifactorial. Exposure to tobacco smoke and the role played by the carcinogenic compounds that it contains would explain the common association between lung cancer and chronic obstructive pulmonary disease (COPD), which is closely linked to tobacco use. In both diseases, sustained inflammation is caused by increased oxidative stress (for example, lipid peroxidation). This generates low molecular weight substances called volatile organic compounds (VOC) that are excreted during breathing. VOC metabolomics provides an indirect measure of oxidative stress. OBJECTIVE: The aim of this study was to establish the relative influence of COPD on the VOC profile in patients with non-small cell lung cancer (NSCLC), by first studying the possible variation of VOC associated with lung cancer histology. PATIENTS AND METHODS: Exhaled air was tested in 107 NSCLC patients, who were divided into 2?ª+groups: NSCLC with COPD and non-COPD with NSCLC. The exhaled air sample was obtained with the BIOVOC(R) sampler, and transferred to desorption tubes for later analysis by thermal desorption-gas chromatography-mass spectrometry. The VOC analysis showed lineal aldehydes and carboxylic acids. RESULTS AND CONCLUSIONS: No statistically significant differences were found in VOC associated with histology. NSCLC and COPD patients present a 1.7-fold (1.1-2.7) greater probability of detection of propionic acid (95% CI: 1.22-6.2) than patients without COPD or NSCLC (p?ª+=?ª+0.013)"
Keywords:		Biomarcadores Biomarkers Chronic obstructive pulmonary disease Compuestos organicos volatiles Cancer de pulmon no microcitico Enfermedad pulmonar obstructiva cronica Non-small cell lung cancer Volatile organic compounds;
Notes:		"PubMed-not-MEDLINEMunoz-Lucas, Maria Angeles Jareno-Esteban, Javier Gutierrez-Ortega, Carlos Lopez-Guijarro, Pablo Collado-Yurrita, Luis Quintana-Diaz, Manuel Callol-Sanchez, Luis eng Spain 2020/12/01 Arch Bronconeumol. 2020 Dec; 56(12):801-805. doi: 10.1016/j.arbr.2020.10.004. Epub 2020 Nov 5"