| Title: | Choosing to urinate. Circuits and mechanisms underlying voluntary urination |
| Author(s): | Mukhopadhyay S; Stowers L; |
| Address: | "Department of Neuroscience, La Jolla, CA, USA; Biomedical Sciences Graduate Program, Scripps Research, La Jolla, CA, USA. Department of Neuroscience, La Jolla, CA, USA. Electronic address: stowers@scripps.edu" |
| DOI: | 10.1016/j.conb.2019.11.004 |
| ISSN/ISBN: | 1873-6882 (Electronic) 0959-4388 (Print) 0959-4388 (Linking) |
| Abstract: | "The decision to urinate is a social behavior that is calculated multiple times a day. Many animals perform urine scent-marking which broadcasts their pheromones to regulate the behavior of others and humans are trained at an early age to urinate only at a socially acceptable time and place. The inability to control when and where to void, that is incontinence, causes extreme social discomfort yet targeted therapeutics are lacking because little is known about the underlying circuits and mechanisms. The use of animal models, neurocircuit analysis, and functional manipulation is beginning to reveal basic logic of the circuit that modulates the decision of when and where to void" |
| Keywords: | "Animals *Behavior, Animal Odorants Pheromones Social Behavior *Urination;" |
| Notes: | "MedlineMukhopadhyay, Sourish Stowers, Lisa eng R01 NS108439/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Review England 2019/12/26 Curr Opin Neurobiol. 2020 Feb; 60:129-135. doi: 10.1016/j.conb.2019.11.004. Epub 2019 Dec 23" |
