| Title: | Breath volatile organic compounds (VOCs) as biomarkers for the diagnosis of pathological conditions: A review |
| Author(s): | Moura PC; Raposo M; Vassilenko V; |
| Address: | "Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), NOVA School of Science and Technology, NOVA University of Lisbon, Campus FCT-UNL, Caparica, Portugal. Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), NOVA School of Science and Technology, NOVA University of Lisbon, Campus FCT-UNL, Caparica, Portugal. Electronic address: mfr@fct.unl.pt. Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), NOVA School of Science and Technology, NOVA University of Lisbon, Campus FCT-UNL, Caparica, Portugal. Electronic address: vv@fct.unl.pt" |
| ISSN/ISBN: | 2320-2890 (Electronic) 2319-4170 (Print) 2319-4170 (Linking) |
| Abstract: | "Normal and abnormal/pathological status of physiological processes in the human organism can be characterized through Volatile Organic Compounds (VOCs) emitted in breath. Recently, a wide range of volatile analytes has risen as biomarkers. These compounds have been addressed in the scientific and medical communities as an extremely valuable metabolic window. Once collected and analysed, VOCs can represent a tool for a rapid, accurate, non-invasive, and painless diagnosis of several diseases and health conditions. These biomarkers are released by exhaled breath, urine, faeces, skin, and several other ways, at trace concentration levels, usually in the ppb(v) (mug/L) range. For this reason, the analytical techniques applied for detecting and clinically exploiting the VOCs are extremely important. The present work reviews the most promising results in the field of breath biomarkers and the most common methods of detection of VOCs. A total of 16 pathologies and the respective database of compounds are addressed. An updated version of the VOCs biomarkers database can be consulted at: https://neomeditec.com/VOCdatabase/" |
| Keywords: | Humans *Volatile Organic Compounds/analysis/metabolism Breath Tests/methods Biomarkers Exhalation Skin Breath sampling Exhaled breath VOCs Volatile organic compounds; |
| Notes: | "MedlineMoura, Pedro Catalao Raposo, Maria Vassilenko, Valentina eng Review 2023/06/20 Biomed J. 2023 Aug; 46(4):100623. doi: 10.1016/j.bj.2023.100623. Epub 2023 Jun 17" |
