| Title: | Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil |
| Author(s): | Morales-Lopez J; Centeno-Alvarez M; Nieto-Camacho A; Lopez MG; Perez-Hernandez E; Perez-Hernandez N; Fernandez-Martinez E; |
| Address: | "a Escuela Nacional de Medicina y Homeopatia , Programa Institucional de Biomedicina Molecular, Instituto Politecnico Nacional , Mexico. b Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada del Instituto Politecnico Nacional , Mexico. c Instituto de Quimica Universidad Nacional Autonoma de Mexico , Mexico. d Unidad Irapuato , Centro de Investigacion y de Estudios Avanzados del IPN , Mexico. e IMSS , Hospital de Ortopedia 'Dr. Victorio de la Fuente Narvaez' , Mexico. f Laboratory of Medicinal Chemistry and Pharmacology. Centro de Investigacion en Biologia de la Reproduccion , Area Academica de Medicina, Universidad Autonoma del Estado de Hidalgo , Pachuca Hidalgo , Mexico" |
| DOI: | 10.1080/13880209.2016.1258424 |
| ISSN/ISBN: | 1744-5116 (Electronic) 1388-0209 (Print) 1388-0209 (Linking) |
| Abstract: | "CONTEXT: There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects. OBJECTIVE: To extract Bocfal EO, to identify and quantify its chemical components, to assess their antioxidant capacity, and to evaluate the hepatoprotective properties of Bocfal EO. MATERIALS AND METHODS: Bocfal EO was obtained using hydrodistillation (200 mm Hg/58 degrees C). The chemical composition was analyzed using GC-MS and was quantified using GC-FID. The antioxidant activity of Bocfal EO and its main constituents was evaluated using TBARS in rat brain homogenates. A Bocfal EO hepatoprotective effect (192 mg/kg) on acute carbon tetrachloride (CT)-induced liver damage was determined in rats using biochemical markers and histological analysis. Diallyl disulphide (DADS) (1 mmol/kg) was used as a control for comparison. RESULTS: Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 +/- 4.92% and dimethyl disulphide (DMDS) 19.29 +/- 2.16% as major constituents. Bocfal EO and DMTS were found to be potent TBARS inhibitors with IC(50) values of 0.51 and 3 mg/L, respectively. Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se, as observed using histopathology. DISCUSSION AND CONCLUSION: The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used" |
| Keywords: | Allyl Compounds/pharmacology Animals Antioxidants/isolation & purification/*pharmacology Brain/*drug effects/metabolism Brassica/*chemistry Carbon Tetrachloride Chemical and Drug Induced Liver Injury/etiology/metabolism/pathology/*prevention & control Dis; |
| Notes: | "MedlineMorales-Lopez, Javier Centeno-Alvarez, Monica Nieto-Camacho, Antonio Lopez, Mercedes G Perez-Hernandez, Elizabeth Perez-Hernandez, Nury Fernandez-Martinez, Eduardo eng Comparative Study England 2016/12/09 Pharm Biol. 2017 Dec; 55(1):233-241. doi: 10.1080/13880209.2016.1258424" |
