| Title: | Classification algorithms for SIFT-MS medical diagnosis |
| Author(s): | Moorhead K; Lee D; Chase JG; Moot A; Ledingham K; Scotter J; Allardyce R; Senthilmohan S; Endre Z; |
| Address: | "Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand. ktm19@student.canterbury.ac.nz" |
| Journal Title: | Annu Int Conf IEEE Eng Med Biol Soc |
| DOI: | 10.1109/IEMBS.2007.4353508 |
| ISSN/ISBN: | 2375-7477 (Print) 2375-7477 (Linking) |
| Abstract: | "Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) is an analytical technique for the real-time quantification of trace gases in air or breath samples. The SIFT-MS system can potentially offer unique capability in the early and rapid detection of a wide variety of diseases, infectious bacteria and patient conditions, by using a classifier to differentiate between control and test groups. By identifying which masses and Volatile Organic Compounds (VOCs) contribute most strongly towards a successful classification, biomarkers for a particular disease state may be discovered. A classification method is presented and validated in a simple study in which saturated nitrogen in tedlar bags was differentiated from dry nitrogen in tedlar bags. Several biomarkers were identified, with the most reliable being N2H(+).H2O, and isotopes and water clusters of H3O(+), as expected. The classifier was then applied in a clinical setting to differentiate between patient breath samples after one and four hours of dialysis treatment. Biomarkers for classification were ammonia, acetaldehyde, ethanol, isoprene and acetone. The model classifies significantly better than random, with an ROC area of 0.89" |
| Keywords: | "*Algorithms Artificial Intelligence Breath Tests/*methods Data Interpretation, Statistical Diagnosis, Computer-Assisted/*methods Gases/*analysis Organic Chemicals/*analysis Pattern Recognition, Automated/*methods Reproducibility of Results Sensitivity and;" |
| Notes: | "MedlineMoorhead, K Lee, D Chase, J G Moot, A Ledingham, K Scotter, J Allardyce, R Senthilmohan, S Endre, Z eng Evaluation Study Research Support, Non-U.S. Gov't 2007/11/16 Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:5178-81. doi: 10.1109/IEMBS.2007.4353508" |
