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Comp Biochem Physiol B Biochem Mol Biol

Title:		The impact of two pesticides on olfactory-mediated endocrine function in mature male Atlantic salmon (Salmo salar L.) parr
Author(s):		Moore A; Lower N;
Address:		"Centre for Environment, Fisheries and Aquaculture Science (CEFAS), Lowestoft Laboratory, Pakefield Road, Lowestoft, NR33 0HT, Suffolk, UK. a.moore@cefas.co.uk"
Journal Title:		Comp Biochem Physiol B Biochem Mol Biol
Year:		2001
Volume:		129
Issue:		2-Mar
Page Number:		269 - 276
DOI:		10.1016/s1096-4959(01)00321-9
ISSN/ISBN:		1096-4959 (Print) 1096-4959 (Linking)
Abstract:		"Short-term exposure of the olfactory epithelium of mature male Atlantic salmon parr to either the pesticide simazine (concentrations 1.0 and 2.0 microg l(-1)) or the pesticide atrazine (concentration 1.0 microg l(-1)) significantly reduced the olfactory response to the female priming pheromone, prostaglandin F(2alpha). In addition, the reproductive priming effect of the pheromone on the levels of expressible milt was also reduced after exposure to the individual pesticides (simazine 0.1, 0.5, 1.0 and 2.0 microg l(-1) and atrazine 0.5 and 2.0 microg l(-1)). When the olfactory epithelium was exposed to a mixture of simazine and atrazine, (concentrations of 0.5:0.5 and 1.0:1.0 microg l(-1)), there was no significant reduction in the olfactory response when compared to the single pesticides at equivalent concentrations. In addition, exposure to a mixture of simazine and atrazine had no synergistic effect on the priming response, and plasma levels of testosterone, 11-ketotestosterone and 17,20beta-dihydroxy-4-pregnen-3-one were similar in the groups of male parr exposed to the individual pesticides. Although the levels of expressible milt were reduced in all groups, there were no significant differences between the different pesticide treatments. The results of the study suggest that the two s-triazine pesticides have an additive and not a synergistic impact on olfactory-mediated endocrine function in mature male salmon parr"
Keywords:		Animals Atrazine/*pharmacology Dinoprost/pharmacology Drug Synergism Endocrine Glands/*drug effects/metabolism Female Ketosteroids/blood Male Olfactory Mucosa/*drug effects/metabolism Pesticides/*pharmacology Pheromones/*pharmacology Salmo salar/blood/*me;
Notes:		"MedlineMoore, A Lower, N eng England 2001/06/12 Comp Biochem Physiol B Biochem Mol Biol. 2001 Jun; 129(2-3):269-76. doi: 10.1016/s1096-4959(01)00321-9"